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学科主题: 临床医学
题名:
MRI及B超对乳腺癌新辅助化疗疗效评价的前瞻性研究
其他题名: Prospective study on the role of MRI and B ultrasonography in evaluating the tumor response to neoadjuvant chemotherapy in breast cancer
作者: 叶京明; 徐玲; 王东民; 赵建新; 张澜波; 段学宁; 刘荫华
关键词: 乳腺肿瘤 ; 磁共振成像 ; 超声检查,乳房 ; 新辅助化疗 ; Breast neoplasms ; Magnetic resonance imaging ; Ultrasonography,mammary ; Neoadjuvant chemotherapy
刊名: 中华外科杂志
发表日期: 2009
DOI: 10.3760/cma.j.issn.0529-5815.2009.05.011
卷: 47, 期:5, 页:349-352
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 观察B超及MRI在乳腺癌新辅助化疗疗效评价中的作用.方法 对2007年7月至2008年7月接受新辅助化疗的85例原发性乳腺癌患者进行前瞻性研究,对比分析手术前新辅助化疗前、化疗2周期后、化疗4周期后患者的B超、MRI影像学资料,参照实体瘤疗效评价标准(RECIST)评价疗效,并与术后组织病理学检查进行比较.结果 人组患者共85例,均完成4周期新辅助化疗.MRI评估完全缓解(CR)者0例,部分缓解(PR)者56例,疾病稳定(SD)者27例,疾病进展(PD)者2例;B超评估CR者0例,PR者52例,sD者31例,PD者2例.MRI及B超对新辅助化疗后残余肿瘤检测的阳性预测值均为94.1%.其中新辅助化疗后残余肿瘤最大径线MRI测茸结果与病理镜下测量结果高度相关(r=0.783,P<0.05),B超对残余肿瘤测量结果与病理镜下测量结果中度相关(r=0.576,P<0.001).结论 MRI是乳腺癌新辅助化疗临床疗效评价的可靠方法,其准确性高于B超. Objective To evaluate the role of breast B ultrasonography and magnetic resonance imaging in assessing the tumor response to neoadjuvant chemotherapy in breast cancer. Methods Eighty-five patients with breast cancer diagnosed by core needle biopsy received neoadjuvant chemotherapy entered this prospective study. Breast B ultrasonography and dynamic enhanced MRI was performed before chemotherapy induction, after the second course and the fourth course of chemotherapy prior to the surgery. Clinical evaluation was made through the tumor reduction measured by B ultrasonography and MRI, based on the response evaluation criteria in solid tumors (RECIST). Results Measured by dynamic enhanced MRI, 56 patients got partial response (PR), 27 got stable disease (SD) and 2 got progressive disease (PD), none complete response (CR). Measured by B uhrasonography, 52 patients got PR, 31 got SD, 2 got PD, no CR. Residual tumor size after chemotherapy on MRI correlated well with post-operative pathologic findings (r =0. 783,P <0. 05), and B ultrasonography correlated moderately with microscopic findings (r =0. 576, P<0.001). Conclusion Dynamic enhanced MR1 is a reliable method to evaluate tumor response to neoadjuvant chemotherapy in breast cancer.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/46819
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 北京大学第一医院乳腺疾病中心,100034

Recommended Citation:
叶京明,徐玲,王东民,等. MRI及B超对乳腺癌新辅助化疗疗效评价的前瞻性研究[J]. 中华外科杂志,2009,47(5):349-352.
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