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学科主题: 临床医学
题名:
外照射联合131I-chTNT对小鼠Lewis瘤影响的研究
其他题名: Effect of irradiation combined with 131I-chTNT on Lewis tumor of mice
作者: 张明1; 高献书1; 张春丽1; 秦尚彬1; 刘朝兴1; 王荣福1
关键词: 小鼠 ; Lewis瘤 ; 照射 ; 131I-chTNT ; Mice ; Lewis tumor ; Irradiation ; 131I-chTNT
刊名: 中华放射医学与防护杂志
发表日期: 2008
DOI: 10.3760/cma.j.issn.0254-5098.2008.03.014
卷: 28, 期:3, 页:255-257
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 研究外照射联合131I-chTNT对荷瘤小鼠肿瘤生长的影响,并观察其在小鼠体内的分布和显像.方法 建立C57小鼠Lewis瘤模型,肿瘤直径达一定大小时随机分组进行实验.测量给药后不同时间肿瘤组织及感兴趣器官的放射性,观察活体显像情况及荷瘤小鼠肿瘤生长延迟效应.结果 联合外照射组肿瘤组织的放射性1、3和5 d均高于单药组,组间差异有统计学意义(P值分别为0.018、0.041和0.024),两组中正常组织的放射性差别无统计学意义(P>0.05).联合组肿瘤区核素显像比单药组强且持续时间长.肿瘤生长效应实验中单药组、外照射组、联合组的绝对延迟时间为3.1、9.1和13.1 d,标准化延迟时间为10 d,131I-chTNT对放射的增益因子为1.08.结论 外照射联合131l-chTNT后可促进其在小鼠体内肿瘤区的浓聚,而对正常组织无影响.联合应用131I-chTNT町提高外照射对荷瘤小鼠的放射效应. Objective To investigate the biodistribution and scintigraphy of Lewis carcinoma of mice with 131I-chTNT combined with or without irradiation,and to study the effects on the tumor growth of mice. Methods When the tumor size in C57 mice bearing Lewis carcinoma in the right leg was big enough,the micewere randomly divided into different groups to receive different treatment.The biodistribution and scintigraphy of 131I-chTNT were observed at varous time after tail-intravenous injection in tumor-bearing mice.The effect of treatment was assessed by tumor growth delay.Results The uptake of 131I-chTNT in tumor tissue Was significantly higher in combined group than in 131I-chTNT group(P<0.05)and there were no more side effects in the combined group(P>0.05).The scintigraphy result showed higher tumor accumulation of 131I-chTNT in combined group than that in 131I-chTNT group.The absolute growth delay for irradiation group,131I-chTNT group and the combined group was 9.1.3.1 and 13.1 days,respectively.The nominal growth delay was 10 days,and the enhancement factor of 131I-chrTNT for RT was 1.08.Conclusions 131I-chTNT combined with irradiation can increase the uptake of 131I-chTNT in tumor without side effects.131I-chTNT can enhance the radiotherapeutic effect for tumor-bearing mice.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/47001
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.北京大学第一医院
2.河北医科大学,石家庄,050011

Recommended Citation:
张明,高献书,张春丽,等. 外照射联合131I-chTNT对小鼠Lewis瘤影响的研究[J]. 中华放射医学与防护杂志,2008,28(3):255-257.
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