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学科主题: 临床医学
题名:
CADASIL患者的中枢前庭功能损害
其他题名: Central vestibular impairment in patients with CADASIL
作者: 赵桂萍1; 唐澍1; 刘旸1; 王朝霞1; 袁云1
关键词: 常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病 ; 眼震电图 ; 前庭功能检查 ; CADASIL ; Electronystagmography ; Vestibular function tests
刊名: 中国神经精神疾病杂志
发表日期: 2010
DOI: 10.3969/j.issn.1002-0152.2010.02.006
卷: 36, 期:2, 页:88-91
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 评价常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL)的前庭功能状态.方法 CADASIL患者和健康志愿者各17名,进行眼震电图检查,包括凝视性眼震试验、自发性眼震试验、水平扫视试验、水平跟踪试验、水平视动性眼震试验和温度试验,比较两组间结果的差异.结果 两组受试者均未发现自发性眼震和凝视性眼震.水平扫视试验中,两组间扫视潜伏期和扫视速度无统计学差异.CADASIL组扫视准确度均低于正常对照组,向左扫视时差异有统计学意义( F=5.751,P <0.05).水平跟踪试验中,CADASIL组跟踪增益值(gain,G)(G左:0.79±0.08,G右:0.76±0.12)小于对照组(G左:0.87±0.04,G右:0.86±0.06),差异有统计学意义( t=-3.739、-2.911,均P <0.05).按照跟踪曲线类型将CADASIL组分为跟踪正常亚组和跟踪异常亚组,发现头晕症状与跟踪运动异常有关( P <0.05).水平视动性眼震试验发现CADASIL组视动性眼震增益值(G左:0.79±0.17,G右:0.78±0.18)小于对照组(G左:0.90±0.08,G右:0.89±0.09),差异有统计学意义( t =-2.342、-2.335,均 P <0.05).1例患者进行了温度试验,表现为固视抑制失败.结论 CADASIL患者存在中枢前庭功能损害,并且与患者的头晕症状有关. Objective To evaluate the vestibular function in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Methods Seventeen CADASIL patients were recruited in the present study and 17 healthy volunteers served as control subjects. Electronystagmogram examinations including gaze nystagmus test, spontaneous nystagmus test, saccade test, pursuit test, optokinetic nystagmus test and caloric test were performed in the subjects. Results Neither patients nor controls had gaze nystagmus or spontaneous nystagmus. There was no difference in the latency and velocity of saccade movement between patients and controls. The accuracy of the saccade movement, the accuracy in leftward saccade, was significantly lower in CADASIL group compared with controls. The pursuit movement gains was also significantly lower in CADASIL group than in control group(G_L:0.79±0.08, G_R:0.76±0.12)(t=-3.739、-2.911,P <0.05) compared with controls(G_L:0.87±0.04, G_R:0.86±0.06).The optokinetic nystagmus gains were significantly decreased in CADASIL group(G_L:0.79±0.17,G_R:0.78±0.18)(t=-2.342、-2.335,P<0.05) compared with controls(G_L:0.90±0.08,G_R:0.89±0.09). The caloric test was performed in one CADASIL patient and the result revealed an incomplete fixing inhibition. CADASIL group was further divided into normal subgroup and abnormal subgroup based on the pursuit curve. The comparison between those two subgroups demonstrated a significant correlation between the pursuit movement and the symptoms of vertigo or dizziness(P<0.05). Conclusions The central vestibular function is impaired in CADASIL patients and the abnormal vestibular function is related to the symptom of vertigo or dizziness in CADASIL patients.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/47201
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.北京大学第一医院,北京,100034
2.北京积水潭医院

Recommended Citation:
赵桂萍,唐澍,刘旸,等. CADASIL患者的中枢前庭功能损害[J]. 中国神经精神疾病杂志,2010,36(2):88-91.
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