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学科主题: 临床医学
题名:
新辅助化疗对乳腺癌组织因子、基质金属蛋白酶-9和蛋白酶激活受体-2的表达及疗效的影响
其他题名: The impact of neoadjuvant chemotherapy on the expression of tissue factor, protease activated receptor-2 and matrix metalloproteinase-9
作者: 赵建新; 林增茂; 段学宁; 刘荫华
关键词: 乳腺癌 ; 组织因子 ; 蛋白酶激活受体-2 ; 基质金属蛋白酶-9 ; 新辅助化疗 ; Breast cancer ; TF ; PAR-2 ; MMP-9 ; Neoadjuvant chemotherapy
刊名: 中国癌症杂志
发表日期: 2013
DOI: 10.3969/j.issn.1007-3969.2013.03.007
期: 3, 页:195-199
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 背景与目的:组织因子(tissuefactor,TF)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)是影响乳腺癌转移和预后的重要因子,蛋白酶激活受体-2(proteinase activated receptor-2,PAR-2)是二者之间的介导因子.本研究旨在探讨乳腺癌组织中TF、PAR-2和MMP-9表达的变化与乳腺癌新辅助化疗疗效的关系.方法:应用二步法免疫组织化学方法检测85例乳腺癌新辅助化疗前后乳腺癌组织中TF、PAR-2和MMP-9的表达,分析新辅助化疗前后其表达的变化与新辅助化疗疗效的关系.结果:85例乳腺癌新辅助化疗患者病理完全缓解率(G5)为8.3%,其他患者在新辅助化疗后TF、PAR-2和MMP-9阳性率均降低,其中MMP-9显著降低(P<0.05).新辅助化疗后,MMP-9表达阳性减弱的患者病理疗效显著好于阳性增强者(P<0.05);TF、MMP-9由阳性转为阴性患者的病理疗效显著好于由阴性转为阳性患者(P<0.05).PAR-2的改变则与病理疗效无显著关系.结论:乳腺癌新辅助化疗后TF、MMP-9的阳性表达降低与病理缓解率相关,有助于判断新辅助化疗疗效. @@@@Background and purpose: TF and MMP-9 are important factors for prognosis and metastasis of breast cancer, PAR-2 is the mediate factor of them, this study aimed to evaluate the change of expressions of TF PAR-2 and MMP-9 in breast cancer patients after neoadjuvant chemotherapy and their correlations with pathologic response. Methods: The expressions of TF, PAR-2 and MMP-9 in 85 breast cancer tissues were examined by immunohistochemical technique (SP) before and after neoadjuvant chemotherapy. Correlation analysis were made between the change of expressions and pathologic response. Results: The strictly pathologic completely response rate (G5) was 8.3% in 85 breast cancer patients after neoadjuvant chemotherapy. The decrease of expression of MMP-9 after neoadjuvant chemotherapy was statistically significant correlations with pathological response (P<0.05). The expression changes of TF and MMP-9 from positive to negative was statistically significant correlated with tumor pathological response(P<0.05). The expression change of PAR-2 showed rarely significant (P>0.05). Conclusion: The decrease of expression of TF and MMP-9 after neoadjuvant chemotherapy have statistically significant correlations with pathological response, would be probably useful for estimating the effect of neoadjuvant chemotherapy.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/47210
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 北京大学第一医院乳腺疾病中心,北京 100034

Recommended Citation:
赵建新,林增茂,段学宁,等. 新辅助化疗对乳腺癌组织因子、基质金属蛋白酶-9和蛋白酶激活受体-2的表达及疗效的影响[J]. 中国癌症杂志,2013(3):195-199.
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