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学科主题: 临床医学
题名:
淋巴细胞输注与淋巴瘤和白血病免疫治疗
其他题名: Lymphocyte infusion with lymphoma and leukemia immunotherapy
作者: 朱平1; 童春容1; 邢海洲1
关键词: 白血病 ; 淋巴瘤 ; 淋巴细胞输注 ; TCR转基因 ; 母子嵌合状态 ; Leukemia ; Lymphoma ; Lymphocyte transfusion ; TCR gene transfer ; Child-maternal microchimerism
刊名: 白血病·淋巴瘤
发表日期: 2010
DOI: 10.3760/cma.j.issn.1009-9921.2010.05.001
卷: 19, 期:5, 页:257-259,261
文章类型: Journal Article
摘要: 进入21世纪以来,淋巴细胞输注在淋巴瘤、白血病,特别是淋巴细胞增殖病的治疗方面取得了令人瞩目的 成就.供者淋巴细胞输注或动员后淋巴细胞输注(DLI/DSI)为移植后复发患者提供了再次缓解的契机,CIK/DC-CIK细胞免疫治疗有非MHC限制性抗肿瘤活性,人工合成肿瘤抗原激活的"CTL"细胞治疗有肿瘤特异性靶向杀伤效应,TCR转基因制备抗肿瘤淋巴细胞为治疗提供了新途径.作者建立的母体淋巴细胞输注(NIMA)疗法既发挥抗瘤/病毒活性,又避免了HLA不合的免疫屏障. Remarkable achievements have been made for lymphocyte infusion of lymphoma and leukemia, especially of lymphoproliferative disease within twenty-first century. The donor lymphocyte infusion or mobilized donor lymphocyte infusion (DLI/DSI) offer an opportunity of second remission for relapse patients post-transplantation. Cytokine-induced killer/DC cytokine-induced killer play an anti-tumor activity beyond non-MHC restricted. Cytotoxic lymphocyte infusion activated by synthetic tumor antigen produces targeted effects of anti-tumor. Transgenic CTL of anti-tumor TCR has brought the dawn in lymphoma and leukemia patients with defective lymphocytes. Maternal lymphocyte infusion play an anti-tumor/viral activity by avoiding the immune barrier of HLA mismatch.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/47390
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.北京大学第一医院血液研究室,100034
2.北京市道培医院

Recommended Citation:
朱平,童春容,邢海洲. 淋巴细胞输注与淋巴瘤和白血病免疫治疗[J]. 白血病·淋巴瘤,2010,19(5):257-259,261.
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