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学科主题: 临床医学
题名:
乳头状肾细胞癌的临床病理表现
其他题名: The clinical and pathological manifestations of papillary renal cell carcinoma
作者: 孔祥田; 曾荔; 宓培; 潘柏年; 夏同礼; 那彦群; 郭应禄
关键词: 肾肿瘤 ; 癌,乳头状 ; 病理学
刊名: 中华泌尿外科杂志
发表日期: 2001
DOI: 10.3760/j:issn:1000-6702.2001.02.004
卷: 22, 期:2, 页:77-80
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨乳头状肾细胞癌的临床病理表现, 提高对此类型肾癌的认识。 方法 回顾性分析9例乳头状肾细胞癌 患者临床病理资料并进行随访 结果 9例乳头状肾细胞癌占同期肾 癌的1.9%,平均发病年龄52岁。无自觉症状者5例,血尿4例。7例行肾癌根治术,1例行 肾输尿管全长切除术,1例行保留肾单位的肿瘤切除术。肿瘤最大径4~15 cm,多位于肾皮 质,淡黄色到金黄色,单灶或多灶性结节状生长。均以乳头或乳头管状结构为主,乳头轴心 可见泡沫细胞。9例均有细胞角蛋白CK7表达。Fuhrman病理分级G1 3例、G2 4例、G3 2例。TNM病理分期pT2 7例、pT3a 1例、pT3bN1V1b 1例。随访7例 无瘤生存36~134个月,1例G2 pT3b者无瘤生存11个月,1例G3 pT3a者13 个月后死于肾癌转移。 结论 乳头状肾细胞癌是少见的肾癌,表 现为低分期,预后好。 Objective To study the clinical and patholo gical manifestations of papillary renal cell carcinoma(PRCC) and to improve the recognization of this subtype of renal cell carcinoma(RCC). Metho ds A retrospective study was done including revewing the clinical do cuments and the pathological sections of 9 cases of PRCC.Follow-up was made in all cases. Results 466 cases of RCC were encountered in our institute between January 1989 and June 30,1999. 9 (1.9%) cases of PRCC were identified.The patients were seven men and two women whose age ranged from 33 to 69 years(mean age 52 years).Four presented with gross hematuria and 5 without any symptom being detected on ultrasound exam in a routine physical examination .Radical nephrectomy was done in 7 patients,resection of kidney and whole ureter was done in one patient,nephron-sparing surgery was done in one patient.The tu mor ranged from 4 to 15 cm in the greatest dimension.Most tumors located in the cortex of kidney with straw yellow or golden yellow appearance.Multifocality was found in five cases.Microscopically,PRCCs were predominantly papillary or tubul opapillary,often with a thick fibrous capsule and foam cells.Cytokeratin 7 was e xpressed in all cases.The Fuhrman's nuclear grade of the PRCC was grade 1 in 3 c ases,grade 2 in 4 and grade 3 in 2.The TNM stage was pT2 in 7 cases,pT3a in one and pT3bN1V1b in one.Seven patients were alive and tumor f ree for 36 months to 134 months with a mean of 85.4 months.One with G3 pT3 b has been alive and tumor free for 11 months.One with G3 pT3a died of metastasis. Conclusions PRCC is an uncommon subtype of RCC in China,it tends to present at an earlier stage and ha s a better prognosis.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/48178
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 北京大学第一医院

Recommended Citation:
孔祥田,曾荔,宓培,等. 乳头状肾细胞癌的临床病理表现[J]. 中华泌尿外科杂志,2001,22(2):77-80.
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