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学科主题: 临床医学
题名:
中国人22例Castleman病的临床特点分析
其他题名: Clinical characteristics of 22 cases of Castleman's disease in China
作者: 李楠; 王仁贵; 王广发; 武淑兰
关键词: Cstleman病 ; 闭塞性细支气管炎 ; 副肿瘤性天疱疮 ; castleman' ; s disease ; bronchiolitis obliterans ; paraneoplastic pemphigus
刊名: 中国现代医学杂志
发表日期: 2004
DOI: 10.3969/j.issn.1005-8982.2004.03.007
卷: 14, 期:3, 页:23-27,30
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的Castleman病是一种少见的慢性淋巴组织增生性疾病,分析22例确诊的Castleman病的临床特点,对其分类提出新见解.方法采用病历回顾性分析方法.结果局灶性Castleman病12例,4例有干咳、腹痛等症状,病理均为透明血管型(HV),手术切除预后好.单一部位肿物合并粘膜皮肤水疱和溃疡6例,HV型5例,混合型(Mix)1例,其中5例出现呼吸困难,严重低氧血症,肺功能为严重阻塞性通气功能障碍,胸片双肺过度充气,CT可见弥漫性支气管扩张,临床符合闭塞性细支气管炎,治疗效果差.多中心性Castleman病4例,浆细胞型(PC)3例,Mix型1例.均有发热,3例浮肿、贫血、血沉加快和γ球蛋白增高,2例有肾功能不全,1例甲状腺功能减退,1例四肢远端神经病变,性激素水平异常,乳腺增生,诊断POEMS综合怔,予糖皮质激素、化疗等治疗,2例缓解,2例效果差,随访3例患者死亡.结论Castleman病临床病变多样,应重视皮肤黏膜型Castleman病.此型与多中心性Castleman均治疗困难. Objective:Castleman's disease is a rare lymphoproliferative disorder that is often classified as hyaUniversity from 1977 Objective:To 2002.Results:Twelve patients with single mass had a good prognosis after operation.Only four of them had nonproductive cough and abdominal pain before operation.Six young patients were described with severe mucocutaneous ulceration and erosion.Tumors were found in the retroperiObjective:Toneum and mediastinum,and pathowas mixed type.Five of them complained of progressive dyspnea with fatal outcome.The clinical features,radiological findings and the pulmonary function tests were consistent with those of bronchiolitis obliterans(BO).Four patients with multicentric CD presented manifestation of multisystem involvement.Three of them died although they had received corticosteroids,chemotherapy and radiation therapy.Conclusions: SympObjective:Toms of CD are diverse.Patients with mucocutaneous erosion frequently had lung involvement.It is different from traditional categories and should be considered as an independent type.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/48313
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 北京大学第一医院,北京,100034

Recommended Citation:
李楠,王仁贵,王广发,等. 中国人22例Castleman病的临床特点分析[J]. 中国现代医学杂志,2004,14(3):23-27,30.
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