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学科主题: 基础医学
题名:
Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor
作者: Wang, Li-En; Zhang, Xue-Qiong; Yin, Yan-Qi; Zhang, Yong-He
关键词: loss of righting reflex ; pentobarbital ; presynaptic 5-HT1A receptors ; spinosin
刊名: JOURNAL OF PHARMACY AND PHARMACOLOGY
发表日期: 2012-02-01
DOI: 10.1111/j.2042-7158.2011.01400.x
卷: 64, 期:2, 页:277-282
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ANTAGONIST P-MPPI ; DORSAL RAPHE NUCLEUS ; 8-OH-DPAT-INDUCED HYPOTHERMIA ; INDUCED SLEEP ; RAT ; WAKEFULNESS ; SEROTONIN ; AGONIST ; AUTORECEPTORS ; PHARMACOLOGY
英文摘要:

Objectives This study investigated whether spinosin potentiates pentobarbital-induced loss of righting reflex (LORR) in mice via 5-HT1A receptors.

Methods Our primary endpoint for sedation was LORR. In addition, the basal rectal temperature was measured.

Key findings The results demonstrated that the 5-HT1A agonist 8-OH-DPAT (s. c.) induced reductions in duration of LORR at 0.1, 0.5 and 1.0 mg/kg (P < 0.01), and prolongation of LORR latency at 0.5 and 1.0 mg/kg (s. c., P < 0.01) in pentobarbital (45 mg/kg, i. p.)-treated mice. This effect of 8-OH-DPAT was antagonized either by 5-HT1A antagonist p-MPPI (5 mg/kg, i. p.) or by spinosin (15 mg/kg, i. g.) with significance, respectively. Co-administration of spinosin and p-MPPI both at ineffective doses (spinosin at 5.0 mg/kg, i. g. and p-MPPI at 1.0 mg/kg, i. p.) showed significant augmentative effects in reducing latency to LORR, and increasing LORR duration (P < 0.01) in pentobarbital-treated mice. On the other hand, spinosin inhibited 8-OH-DPAT-induced hypothermia, which has been generally attributed to the activation of somatodendritic 5-HT1A autoreceptors in mice.

Conclusions Based on our previous results and the present data, it should be presumed that presynaptic 5-HT1A autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice.

语种: 英语
所属项目编号: 2009ZX09103-124 ; 30640070 ; 30772556 ; 20100001110048 ; 985
项目资助者: National Scientific &amp ; Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University
WOS记录号: WOS:000298796300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49845
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Li-En,Zhang, Xue-Qiong,Yin, Yan-Qi,et al. Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2012,64(2):277-282.
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