北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 药理学系  > 期刊论文
学科主题: 基础医学
题名:
Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor
作者: Wang, Li-En; Zhang, Xue-Qiong; Yin, Yan-Qi; Zhang, Yong-He
关键词: loss of righting reflex ; pentobarbital ; presynaptic 5-HT1A receptors ; spinosin
刊名: JOURNAL OF PHARMACY AND PHARMACOLOGY
发表日期: 2012-02-01
DOI: 10.1111/j.2042-7158.2011.01400.x
卷: 64, 期:2, 页:277-282
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ANTAGONIST P-MPPI ; DORSAL RAPHE NUCLEUS ; 8-OH-DPAT-INDUCED HYPOTHERMIA ; INDUCED SLEEP ; RAT ; WAKEFULNESS ; SEROTONIN ; AGONIST ; AUTORECEPTORS ; PHARMACOLOGY
英文摘要:

Objectives This study investigated whether spinosin potentiates pentobarbital-induced loss of righting reflex (LORR) in mice via 5-HT1A receptors.

Methods Our primary endpoint for sedation was LORR. In addition, the basal rectal temperature was measured.

Key findings The results demonstrated that the 5-HT1A agonist 8-OH-DPAT (s. c.) induced reductions in duration of LORR at 0.1, 0.5 and 1.0 mg/kg (P < 0.01), and prolongation of LORR latency at 0.5 and 1.0 mg/kg (s. c., P < 0.01) in pentobarbital (45 mg/kg, i. p.)-treated mice. This effect of 8-OH-DPAT was antagonized either by 5-HT1A antagonist p-MPPI (5 mg/kg, i. p.) or by spinosin (15 mg/kg, i. g.) with significance, respectively. Co-administration of spinosin and p-MPPI both at ineffective doses (spinosin at 5.0 mg/kg, i. g. and p-MPPI at 1.0 mg/kg, i. p.) showed significant augmentative effects in reducing latency to LORR, and increasing LORR duration (P < 0.01) in pentobarbital-treated mice. On the other hand, spinosin inhibited 8-OH-DPAT-induced hypothermia, which has been generally attributed to the activation of somatodendritic 5-HT1A autoreceptors in mice.

Conclusions Based on our previous results and the present data, it should be presumed that presynaptic 5-HT1A autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice.

语种: 英语
所属项目编号: 2009ZX09103-124 ; 30640070 ; 30772556 ; 20100001110048 ; 985
项目资助者: National Scientific &amp ; Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University
WOS记录号: WOS:000298796300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49845
Appears in Collections:基础医学院_药理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Li-En,Zhang, Xue-Qiong,Yin, Yan-Qi,et al. Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2012,64(2):277-282.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Li-En]'s Articles
[Zhang, Xue-Qiong]'s Articles
[Yin, Yan-Qi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Li-En]‘s Articles
[Zhang, Xue-Qiong]‘s Articles
[Yin, Yan-Qi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace