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学科主题临床医学
Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer
Zhao Jian-xin2; Liu Yin-hua2; Ye Jing-ming2; Xu Ling1; Huang Qing-yun2; Duan Xue-ning2; Qin Nai-shan3; Wang Xiao-ying3
关键词Breast Cancer Neoadjuvant Chemotherapy Mri Time-signal Intensity Curve Response Evaluation
刊名CHINESE MEDICAL JOURNAL
2011-01-20
DOI10.3760/cma.j.issn.0366-6999.2011.02.007
124期:2页:194-198
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SOLID TUMORS ; MAMMOGRAPHY ; WOMEN ; MRI
英文摘要

Background Use of neoadjuvant chemotherapy necessitates assessment of response to cytotoxic drugs. The aim of this research was to investigate the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (MRI) for evaluating clinical responses to neoadjuvant chemotherapy in breast cancer patients.

Methods We examined patients receiving neoadjuvant chemotherapy for primary breast cancer between October 2007 and September 2008. Dynamic contrast-enhanced MRI was used to examine breast tumors prior to and after neoadjuvant chemotherapy. The MRI examination assessed tumors using Response Evaluation Criteria in Solid Tumors (RECIST). The Miller-Payne grading system was used as a histopathological examination to assess the effect of the treatment. We examined the relationship between the results of RECIST and histopathological criteria. In addition, we used time-signal intensity curves (MRI T-SI) to further evaluate the effects of neoadjuvant chemotherapy on tumor response.

Results MRI examination of patients completing four three-week anthracycline-taxanes chemotherapy treatment revealed that no patients had complete responses (CR), 58 patients had partial responses (PR), 29 patients had stable disease (SD), and four with progressive disease (PD). The effectiveness of neoadjuvant chemotherapy (CR + PR) was 63.7% (58/91). The postoperative histopathological evaluations revealed the following: seven G5 (pCR) cases (7.7%), 39 G4 cases (42.9%), 16 G3 cases (17.6%), 23 G2 cases (25.3%), and six G1 cases (6.6%). The effectiveness (G5 + G4 + G3) was 68.1% (62/91). MRI T-SI standards classified 53 responding cases, 29 stable cases, and nine progressing cases. These results indicated that the treatment was 58.2% effective (53/91) overall.

Conclusions Dynamic contrast-enhanced MRI and histopathological standards were highly correlated. Importantly, MRI T-SI evaluation was found to be useful in assessing the clinical effectiveness of neoadjuvant chemotherapy. Chin Med J 2011;124(2):194-198

语种英语
WOS记录号WOS:000286787300007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49846
专题北京大学第一临床医学院_医学影像科
北京大学第一临床医学院_普通外科
北京大学第一临床医学院_肿瘤化疗科
作者单位1.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Med Oncol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Gen Surg, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhao Jian-xin,Liu Yin-hua,Ye Jing-ming,et al. Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer[J]. CHINESE MEDICAL JOURNAL,2011,124(2):194-198.
APA Zhao Jian-xin.,Liu Yin-hua.,Ye Jing-ming.,Xu Ling.,Huang Qing-yun.,...&Wang Xiao-ying.(2011).Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer.CHINESE MEDICAL JOURNAL,124(2),194-198.
MLA Zhao Jian-xin,et al."Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer".CHINESE MEDICAL JOURNAL 124.2(2011):194-198.
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