|Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer|
|Zhao Jian-xin2; Liu Yin-hua2; Ye Jing-ming2; Xu Ling1; Huang Qing-yun2; Duan Xue-ning2; Qin Nai-shan3; Wang Xiao-ying3|
|关键词||Breast Cancer Neoadjuvant Chemotherapy Mri Time-signal Intensity Curve Response Evaluation|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||SOLID TUMORS ; MAMMOGRAPHY ; WOMEN ; MRI|
Background Use of neoadjuvant chemotherapy necessitates assessment of response to cytotoxic drugs. The aim of this research was to investigate the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (MRI) for evaluating clinical responses to neoadjuvant chemotherapy in breast cancer patients.
Methods We examined patients receiving neoadjuvant chemotherapy for primary breast cancer between October 2007 and September 2008. Dynamic contrast-enhanced MRI was used to examine breast tumors prior to and after neoadjuvant chemotherapy. The MRI examination assessed tumors using Response Evaluation Criteria in Solid Tumors (RECIST). The Miller-Payne grading system was used as a histopathological examination to assess the effect of the treatment. We examined the relationship between the results of RECIST and histopathological criteria. In addition, we used time-signal intensity curves (MRI T-SI) to further evaluate the effects of neoadjuvant chemotherapy on tumor response.
Results MRI examination of patients completing four three-week anthracycline-taxanes chemotherapy treatment revealed that no patients had complete responses (CR), 58 patients had partial responses (PR), 29 patients had stable disease (SD), and four with progressive disease (PD). The effectiveness of neoadjuvant chemotherapy (CR + PR) was 63.7% (58/91). The postoperative histopathological evaluations revealed the following: seven G5 (pCR) cases (7.7%), 39 G4 cases (42.9%), 16 G3 cases (17.6%), 23 G2 cases (25.3%), and six G1 cases (6.6%). The effectiveness (G5 + G4 + G3) was 68.1% (62/91). MRI T-SI standards classified 53 responding cases, 29 stable cases, and nine progressing cases. These results indicated that the treatment was 58.2% effective (53/91) overall.
Conclusions Dynamic contrast-enhanced MRI and histopathological standards were highly correlated. Importantly, MRI T-SI evaluation was found to be useful in assessing the clinical effectiveness of neoadjuvant chemotherapy. Chin Med J 2011;124(2):194-198
|作者单位||1.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Med Oncol, Beijing 100034, Peoples R China|
2.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Gen Surg, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Radiol, Beijing 100034, Peoples R China
|Zhao Jian-xin,Liu Yin-hua,Ye Jing-ming,et al. Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer[J]. CHINESE MEDICAL JOURNAL,2011,124(2):194-198.|
|APA||Zhao Jian-xin.,Liu Yin-hua.,Ye Jing-ming.,Xu Ling.,Huang Qing-yun.,...&Wang Xiao-ying.(2011).Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer.CHINESE MEDICAL JOURNAL,124(2),194-198.|
|MLA||Zhao Jian-xin,et al."Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer".CHINESE MEDICAL JOURNAL 124.2(2011):194-198.|