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学科主题: 临床医学
题名:
Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer
作者: Zhao Jian-xin2; Liu Yin-hua2; Ye Jing-ming2; Xu Ling1; Huang Qing-yun2; Duan Xue-ning2; Qin Nai-shan3; Wang Xiao-ying3
关键词: breast cancer ; neoadjuvant chemotherapy ; MRI ; time-signal intensity curve ; response evaluation
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-01-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.02.007
卷: 124, 期:2, 页:194-198
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SOLID TUMORS ; MAMMOGRAPHY ; WOMEN ; MRI
英文摘要:

Background Use of neoadjuvant chemotherapy necessitates assessment of response to cytotoxic drugs. The aim of this research was to investigate the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (MRI) for evaluating clinical responses to neoadjuvant chemotherapy in breast cancer patients.

Methods We examined patients receiving neoadjuvant chemotherapy for primary breast cancer between October 2007 and September 2008. Dynamic contrast-enhanced MRI was used to examine breast tumors prior to and after neoadjuvant chemotherapy. The MRI examination assessed tumors using Response Evaluation Criteria in Solid Tumors (RECIST). The Miller-Payne grading system was used as a histopathological examination to assess the effect of the treatment. We examined the relationship between the results of RECIST and histopathological criteria. In addition, we used time-signal intensity curves (MRI T-SI) to further evaluate the effects of neoadjuvant chemotherapy on tumor response.

Results MRI examination of patients completing four three-week anthracycline-taxanes chemotherapy treatment revealed that no patients had complete responses (CR), 58 patients had partial responses (PR), 29 patients had stable disease (SD), and four with progressive disease (PD). The effectiveness of neoadjuvant chemotherapy (CR + PR) was 63.7% (58/91). The postoperative histopathological evaluations revealed the following: seven G5 (pCR) cases (7.7%), 39 G4 cases (42.9%), 16 G3 cases (17.6%), 23 G2 cases (25.3%), and six G1 cases (6.6%). The effectiveness (G5 + G4 + G3) was 68.1% (62/91). MRI T-SI standards classified 53 responding cases, 29 stable cases, and nine progressing cases. These results indicated that the treatment was 58.2% effective (53/91) overall.

Conclusions Dynamic contrast-enhanced MRI and histopathological standards were highly correlated. Importantly, MRI T-SI evaluation was found to be useful in assessing the clinical effectiveness of neoadjuvant chemotherapy. Chin Med J 2011;124(2):194-198

语种: 英语
所属项目编号: D090507043409010
项目资助者: Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000286787300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49846
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Med Oncol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Gen Surg, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Radiol, Beijing 100034, Peoples R China

Recommended Citation:
Zhao Jian-xin,Liu Yin-hua,Ye Jing-ming,et al. Effectiveness of dynamic contrast-enhanced magnetic resonance imaging in evaluating clinical responses to neoadjuvant chemotherapy in breast cancer[J]. CHINESE MEDICAL JOURNAL,2011,124(2):194-198.
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