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学科主题基础医学
Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21)
Ren, An-Jing1; Yuan, Xin1; Lin, Li1; Xu, Jing1; Chen, Ting1; Wang, Wei-Zhong1; Yan, Xiao-Hong1; Qing, Yong-Wen1; Tang, Chao-Shu1; Yuan, Wen-Jun1
关键词Endothelin-1(1-31) Arrhythmia Rats Hearts Phosphoramidon
刊名EXPERIMENTAL BIOLOGY AND MEDICINE
2006-06-01
231期:6页:937-941
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]SMOOTH-MUSCLE-CELLS ; RNA ANTISENSE OLIGODEOXYNUCLEOTIDES ; ISCHEMIC ARRHYTHMIAS ; CORONARY-ARTERY ; RATS ; PROLIFERATION ; PEPTIDE ; KINASE
英文摘要

Endothelin (ET)-1(1-21) is known to play an important role in the pathogenesis of acute ischemic arrhythmia. In the present study, we attempted to determine whether administration of ET-1(1-31) would result in arrhythmia in perfused isolated rat hearts. Forty-eight Sprague-Dawley rats weighing similar to 250-350 g were randomized into 6 groups. Heart was isolated and perfused in a Langendorff mode. The effects of ET-1(1-31) on arrhythmia, heart rate, coronary flow, and heart function were analyzed. Perfusion with 1 nM ET-1(1-31) resulted in frequent ventricular ectopic beats (VEBs) and ventricular tachycardia (VT). Overall VEB was 128.0 (similar to 66.0-1015.0), and the arrhythmia score (AS) was 2.18 +/- 0.87; both were significantly higher than those of the control group (P < 0.01). Pretreatment with perfusion of 10 nM of the ETA-receptor antagonist BQ(123) markedly attenuated the occurrence of VEB and VT induced by ET-11-31. AS in 10 nM BQ123 group was significantly lower than that in I nM ET-11-31 group (P < 0.01). The arrhythmia induced by 1 nM ET-1(1-31) was partially but significantly reduced by phosphoramidon (1 pM), a neutral endopeptidase/ET-converting enzyme inhibitor. ET-1(1-31) per se caused arrhythmia in perfused isolated rat hearts. This arrhythmogenic action is in part mediated by ETA receptor and may be attributed mainly to the conversion of ET-1(1-31) to ET-1(1-21).

语种英语
WOS记录号WOS:000237934600048
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49847
专题基础医学院_生理学与病理生理学系
作者单位1.Second Mil Med Univ, Basic Med Coll, Dept Physiol, Shanghai, Peoples R China
2.Changhai Hosp, Dept Cardiovasc Med, Shanghai, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ren, An-Jing,Yuan, Xin,Lin, Li,et al. Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21)[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2006,231(6):937-941.
APA Ren, An-Jing.,Yuan, Xin.,Lin, Li.,Xu, Jing.,Chen, Ting.,...&Yuan, Wen-Jun.(2006).Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21).EXPERIMENTAL BIOLOGY AND MEDICINE,231(6),937-941.
MLA Ren, An-Jing,et al."Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21)".EXPERIMENTAL BIOLOGY AND MEDICINE 231.6(2006):937-941.
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