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学科主题: 临床医学
题名:
Non-invasive evaluation of hemodynamics in pulmonary hypertension by a Septal angle measured by computed tomography pulmonary angiography: Comparison with right-heart catheterization and association with N-terminal pro-B-type natriuretic peptide
作者: Tang, Qiang1; Liu, Min2; Ma, Zhanhong2; Guo, Xiaojuan2; Kuang, Tuguang3; Yang, Yuanhua3
关键词: pulmonary hypertension ; computer tomographic pulmonary angiography ; N-terminal pro-B-type natriuretic peptide
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2013-12-01
DOI: 10.3892/etm.2013.1324
卷: 6, 期:6, 页:1350-1358
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: RIGHT-VENTRICULAR DYSFUNCTION ; ARTERIAL-HYPERTENSION ; VASCULAR-RESISTANCE ; DISEASE SEVERITY ; CARDIAC-OUTPUT ; DIAGNOSIS ; PRESSURE ; EMBOLISM ; FAILURE ; CT
英文摘要:

The septal angle, an angle between the interventricular septum and the line connecting the sternum midpoint and thoracic vertebral spinous process, as measured by computed tomographic pulmonary angiography (CTPA), has been observed to be increased in patients with pulmonary hypertension (PH), but its meaning remains unclear. The aim of this study was to investigate the potential role of the septal angle in evaluating hemodynamics and its association with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with PH. Patients with PH (n=106), including 76 with chronic thromboembolic pulmonary hypertension (CTEPH) and 30 with pulmonary artery hypertension (PAH), were retrospectively reviewed. The patients underwent CTPA prior to right-heart catheterization. The septal angle was measured on transversal CTPA images. Hemodynamic parameters were evaluated by right-heart catheterization. The level of plasma NT-proBNP was measured by enzyme-linked sandwich immunoassay. The septal angle had a moderate correlation with cardiac output (CO; r=-0.535, P=0.000) and a high correlation with pulmonary vascular resistance (PVR; r=0.642, P=0.000). The mean level of NT-proBNP in PH was 1,716.09 +/- 1,498.30 pg/ml, which correlated with the septal angle (r=0.693, P=0.000). In a stepwise forward regression analysis, the Septal angle was entered into the final equation for predicting PVR, leading to the following equation: PVR = 28.256 x Septal angle - 728.72. In CTEPH, the Septal angle strongly correlated with NT-proBNP (r=0.668, P=0.000) and PVR (r=0.676, P=0.000). In PAH, the Septal angle strongly correlated with NT-proBNP (r=0.616, P=0.003) and PVR (r=0.623, P=0.000). The CTPA-derived Septal angle is a superior predictor for evaluating and monitoring the level of NT-proBNP and PVR in patients with PH.

语种: 英语
所属项目编号: Z121107001012126
项目资助者: Beijing Clinical Medical Research Foundation
WOS记录号: WOS:000330782800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49848
Appears in Collections:北京大学首钢医院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Shougang Hosp, Dept Cardiol, Beijing 100144, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing 100020, Peoples R China
3.Capital Med Univ, Resp Dis Res Ctr, Beijing 100020, Peoples R China

Recommended Citation:
Tang, Qiang,Liu, Min,Ma, Zhanhong,et al. Non-invasive evaluation of hemodynamics in pulmonary hypertension by a Septal angle measured by computed tomography pulmonary angiography: Comparison with right-heart catheterization and association with N-terminal pro-B-type natriuretic peptide[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,6(6):1350-1358.
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