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Non-invasive evaluation of hemodynamics in pulmonary hypertension by a Septal angle measured by computed tomography pulmonary angiography: Comparison with right-heart catheterization and association with N-terminal pro-B-type natriuretic peptide
Tang, Qiang1; Liu, Min2; Ma, Zhanhong2; Guo, Xiaojuan2; Kuang, Tuguang3; Yang, Yuanhua3
关键词Pulmonary Hypertension Computer Tomographic Pulmonary Angiography N-terminal Pro-b-type Natriuretic Peptide
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2013-12-01
DOI10.3892/etm.2013.1324
6期:6页:1350-1358
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]RIGHT-VENTRICULAR DYSFUNCTION ; ARTERIAL-HYPERTENSION ; VASCULAR-RESISTANCE ; DISEASE SEVERITY ; CARDIAC-OUTPUT ; DIAGNOSIS ; PRESSURE ; EMBOLISM ; FAILURE ; CT
英文摘要

The septal angle, an angle between the interventricular septum and the line connecting the sternum midpoint and thoracic vertebral spinous process, as measured by computed tomographic pulmonary angiography (CTPA), has been observed to be increased in patients with pulmonary hypertension (PH), but its meaning remains unclear. The aim of this study was to investigate the potential role of the septal angle in evaluating hemodynamics and its association with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with PH. Patients with PH (n=106), including 76 with chronic thromboembolic pulmonary hypertension (CTEPH) and 30 with pulmonary artery hypertension (PAH), were retrospectively reviewed. The patients underwent CTPA prior to right-heart catheterization. The septal angle was measured on transversal CTPA images. Hemodynamic parameters were evaluated by right-heart catheterization. The level of plasma NT-proBNP was measured by enzyme-linked sandwich immunoassay. The septal angle had a moderate correlation with cardiac output (CO; r=-0.535, P=0.000) and a high correlation with pulmonary vascular resistance (PVR; r=0.642, P=0.000). The mean level of NT-proBNP in PH was 1,716.09 +/- 1,498.30 pg/ml, which correlated with the septal angle (r=0.693, P=0.000). In a stepwise forward regression analysis, the Septal angle was entered into the final equation for predicting PVR, leading to the following equation: PVR = 28.256 x Septal angle - 728.72. In CTEPH, the Septal angle strongly correlated with NT-proBNP (r=0.668, P=0.000) and PVR (r=0.676, P=0.000). In PAH, the Septal angle strongly correlated with NT-proBNP (r=0.616, P=0.003) and PVR (r=0.623, P=0.000). The CTPA-derived Septal angle is a superior predictor for evaluating and monitoring the level of NT-proBNP and PVR in patients with PH.

语种英语
WOS记录号WOS:000330782800002
项目编号Z121107001012126
资助机构Beijing Clinical Medical Research Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49848
专题北京大学首钢医院_心血管内科
作者单位1.Peking Univ, Shougang Hosp, Dept Cardiol, Beijing 100144, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing 100020, Peoples R China
3.Capital Med Univ, Resp Dis Res Ctr, Beijing 100020, Peoples R China
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GB/T 7714
Tang, Qiang,Liu, Min,Ma, Zhanhong,et al. Non-invasive evaluation of hemodynamics in pulmonary hypertension by a Septal angle measured by computed tomography pulmonary angiography: Comparison with right-heart catheterization and association with N-terminal pro-B-type natriuretic peptide[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,6(6):1350-1358.
APA Tang, Qiang,Liu, Min,Ma, Zhanhong,Guo, Xiaojuan,Kuang, Tuguang,&Yang, Yuanhua.(2013).Non-invasive evaluation of hemodynamics in pulmonary hypertension by a Septal angle measured by computed tomography pulmonary angiography: Comparison with right-heart catheterization and association with N-terminal pro-B-type natriuretic peptide.EXPERIMENTAL AND THERAPEUTIC MEDICINE,6(6),1350-1358.
MLA Tang, Qiang,et al."Non-invasive evaluation of hemodynamics in pulmonary hypertension by a Septal angle measured by computed tomography pulmonary angiography: Comparison with right-heart catheterization and association with N-terminal pro-B-type natriuretic peptide".EXPERIMENTAL AND THERAPEUTIC MEDICINE 6.6(2013):1350-1358.
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