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IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects
作者: Qiao, Jie1; Wang, Zhen-Bo2; Feng, Huai-Liang3; Miao, Yi-Liang4; Wang, Qiang5; Yu, Yang1; Wei, Yan-Chang2; Yan, Jie1; Wang, Wei-Hua6; Shen, Wei7; Sun, Shao-Chen8; Schatten, Heide9; Sun, Qing-Yuan2
关键词: Infertility ; Maternal age ; Oocyte ; Ovary ; Assited reproductive technology
刊名: MOLECULAR ASPECTS OF MEDICINE
发表日期: 2014-08-01
DOI: 10.1016/j.mam.2013.06.001
卷: 38, 期:SI, 页:54-85
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ; Research & Experimental Medicine
关键词[WOS]: EMBRYONIC STEM-CELLS ; IN-VITRO FERTILIZATION ; PREIMPLANTATION GENETIC DIAGNOSIS ; GERMINAL VESICLE TRANSFER ; HUMAN OVARIAN TISSUE ; HUMAN CHORIONIC-GONADOTROPIN ; BONE-MARROW-TRANSPLANTATION ; INTRACYTOPLASMIC SPERM INJECTION ; RANDOMIZED CONTROLLED-TRIAL ; POLARIZED-LIGHT MICROSCOPY
英文摘要:

It is well known that maternal ageing not only causes increased spontaneous abortion and reduced fertility, but it is also a high genetic disease risk Although assisted reproductive technologies (ARTs) have been widely used to treat infertility, the overall success is still low. The main reasons for age-related changes include reduced follicle number, compromised oocyte quality especially aneuploidy, altered reproductive endocrinology, and increased reproductive tract defect. Various approaches for improving or treating infertility in aged women including controlled ovarian hyperstimulation with intrauterine insemination (IUI), IVF/ICSI-ET, ovarian reserve testing, preimplantation genetic diagnosis and screening (PGD/PGS), oocyte selection and donation, oocyte and ovary tissue cryopreservation before ageing, miscarriage prevention, and caloric restriction are summarized in this review. Future potential reproductive techniques for infertile older women including oocyte and zygote micromanipulations, derivation of oocytes from germ stem cells, ES cells, and iPS cells, as well as through bone marrow transplantation are discussed. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011CB944500 ; 2012CB944404 ; 30930065
项目资助者: Major State Basic Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000341538700002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49850
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
3.Cornell Univ, Weill Med Coll, New York Hosp Queens, Dept Lab Med, New York, NY 10021 USA
4.NIEHS, Reprod Med Grp, Lab Reprod & Dev Toxicol, NIH, Res Triangle Pk, NC 27709 USA
5.Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA
6.Tomball Reg Hosp, Houston Fertil Inst, Tomball, TX 77375 USA
7.Qingdao Agr Univ, Dept Anim Sci, Lab Germ Cell Biol, Qingdao 266109, Peoples R China
8.Nanjing Agr Univ, Dept Anim Sci, Nanjing 210095, Jiangsu, Peoples R China
9.Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA

Recommended Citation:
Qiao, Jie,Wang, Zhen-Bo,Feng, Huai-Liang,et al. The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects[J]. MOLECULAR ASPECTS OF MEDICINE,2014,38(SI):54-85.
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