IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects
Qiao, Jie1; Wang, Zhen-Bo2; Feng, Huai-Liang3; Miao, Yi-Liang4; Wang, Qiang5; Yu, Yang1; Wei, Yan-Chang2; Yan, Jie1; Wang, Wei-Hua6; Shen, Wei7; Sun, Shao-Chen8; Schatten, Heide9; Sun, Qing-Yuan2
关键词Infertility Maternal Age Oocyte Ovary Assited Reproductive Technology
刊名MOLECULAR ASPECTS OF MEDICINE
2014-08-01
DOI10.1016/j.mam.2013.06.001
38期:SI页:54-85
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Medicine, Research & Experimental
研究领域[WOS]Biochemistry & Molecular Biology ; Research & Experimental Medicine
关键词[WOS]EMBRYONIC STEM-CELLS ; IN-VITRO FERTILIZATION ; PREIMPLANTATION GENETIC DIAGNOSIS ; GERMINAL VESICLE TRANSFER ; HUMAN OVARIAN TISSUE ; HUMAN CHORIONIC-GONADOTROPIN ; BONE-MARROW-TRANSPLANTATION ; INTRACYTOPLASMIC SPERM INJECTION ; RANDOMIZED CONTROLLED-TRIAL ; POLARIZED-LIGHT MICROSCOPY
英文摘要

It is well known that maternal ageing not only causes increased spontaneous abortion and reduced fertility, but it is also a high genetic disease risk Although assisted reproductive technologies (ARTs) have been widely used to treat infertility, the overall success is still low. The main reasons for age-related changes include reduced follicle number, compromised oocyte quality especially aneuploidy, altered reproductive endocrinology, and increased reproductive tract defect. Various approaches for improving or treating infertility in aged women including controlled ovarian hyperstimulation with intrauterine insemination (IUI), IVF/ICSI-ET, ovarian reserve testing, preimplantation genetic diagnosis and screening (PGD/PGS), oocyte selection and donation, oocyte and ovary tissue cryopreservation before ageing, miscarriage prevention, and caloric restriction are summarized in this review. Future potential reproductive techniques for infertile older women including oocyte and zygote micromanipulations, derivation of oocytes from germ stem cells, ES cells, and iPS cells, as well as through bone marrow transplantation are discussed. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000341538700002
项目编号2011CB944500 ; 2012CB944404 ; 30930065
资助机构Major State Basic Research Program ; National Natural Science Foundation of China
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49850
专题北京大学第三临床医学院_生殖医学中心
北京大学第二临床医学院_麻醉科
北京大学第三临床医学院_妇产科
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
3.Cornell Univ, Weill Med Coll, New York Hosp Queens, Dept Lab Med, New York, NY 10021 USA
4.NIEHS, Reprod Med Grp, Lab Reprod & Dev Toxicol, NIH, Res Triangle Pk, NC 27709 USA
5.Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA
6.Tomball Reg Hosp, Houston Fertil Inst, Tomball, TX 77375 USA
7.Qingdao Agr Univ, Dept Anim Sci, Lab Germ Cell Biol, Qingdao 266109, Peoples R China
8.Nanjing Agr Univ, Dept Anim Sci, Nanjing 210095, Jiangsu, Peoples R China
9.Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA
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GB/T 7714
Qiao, Jie,Wang, Zhen-Bo,Feng, Huai-Liang,et al. The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects[J]. MOLECULAR ASPECTS OF MEDICINE,2014,38(SI):54-85.
APA Qiao, Jie.,Wang, Zhen-Bo.,Feng, Huai-Liang.,Miao, Yi-Liang.,Wang, Qiang.,...&Sun, Qing-Yuan.(2014).The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects.MOLECULAR ASPECTS OF MEDICINE,38(SI),54-85.
MLA Qiao, Jie,et al."The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects".MOLECULAR ASPECTS OF MEDICINE 38.SI(2014):54-85.
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