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Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex
Wei, Yong-Biao1,2,3; Yang, Xiao-Da1,2
关键词Bis ((5-hydroxy-4-oxo-4h-pyran-2-yl)Methyl Benzoatato) Oxovanadium (Iv) Diabetes Mellitus Blood Glucose Antioxidants
刊名BIOMETALS
2012-12-01
DOI10.1007/s10534-012-9587-x
25期:6页:1261-1268
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者NSFC ; Major New Medicine Projiect in Mega-projiects of Science Research of China ; NSFC ; Major New Medicine Projiect in Mega-projiects of Science Research of China
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]AGENT ; BIS(ALPHA-FURANCARBOXYLATO)OXOVANADIUM(IV) ; RATS ; MICE
英文摘要

Vanadium complexes are potent hypoglycemic agents and of great potential for therapeutical treatment of diabetes. In the present work, a novel vanadium compound, bis ((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl benzoatato) oxovanadium (IV) (BBOV) has been synthesized. Treatment of STZ-induced diabetic rats with BBOV restored the blood glucose to normal level and ameliorated glucose tolerance. The hypoglycemic effect of BBOV is similar to that of bis (maltolato) oxovanadium but is less toxic in median lethal dose. Overall, the present work will provide useful information for further development of new anti-diabetic vanadium compounds.

语种英语
所属项目编号20971008 ; 2009ZX09502-006
资助者NSFC ; Major New Medicine Projiect in Mega-projiects of Science Research of China ; NSFC ; Major New Medicine Projiect in Mega-projiects of Science Research of China
WOS记录号WOS:000310990900014
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49853
Collection北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Guangxi Med Univ, Sch Pharmaceut Sci, Nanning 530021, Guangxi, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yong-Biao,Yang, Xiao-Da. Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex[J]. BIOMETALS,2012,25(6):1261-1268.
APA Wei, Yong-Biao,&Yang, Xiao-Da.(2012).Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex.BIOMETALS,25(6),1261-1268.
MLA Wei, Yong-Biao,et al."Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex".BIOMETALS 25.6(2012):1261-1268.
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