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学科主题: 药学
题名:
Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex
作者: Wei, Yong-Biao1,2,3; Yang, Xiao-Da1,2
关键词: Bis ((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl benzoatato) oxovanadium (IV) ; Diabetes mellitus ; Blood glucose ; Antioxidants
刊名: BIOMETALS
发表日期: 2012-12-01
DOI: 10.1007/s10534-012-9587-x
卷: 25, 期:6, 页:1261-1268
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: AGENT ; BIS(ALPHA-FURANCARBOXYLATO)OXOVANADIUM(IV) ; RATS ; MICE
英文摘要:

Vanadium complexes are potent hypoglycemic agents and of great potential for therapeutical treatment of diabetes. In the present work, a novel vanadium compound, bis ((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl benzoatato) oxovanadium (IV) (BBOV) has been synthesized. Treatment of STZ-induced diabetic rats with BBOV restored the blood glucose to normal level and ameliorated glucose tolerance. The hypoglycemic effect of BBOV is similar to that of bis (maltolato) oxovanadium but is less toxic in median lethal dose. Overall, the present work will provide useful information for further development of new anti-diabetic vanadium compounds.

语种: 英语
所属项目编号: 20971008 ; 2009ZX09502-006
项目资助者: NSFC ; Major New Medicine Projiect in Mega-projiects of Science Research of China
WOS记录号: WOS:000310990900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49853
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Guangxi Med Univ, Sch Pharmaceut Sci, Nanning 530021, Guangxi, Peoples R China

Recommended Citation:
Wei, Yong-Biao,Yang, Xiao-Da. Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex[J]. BIOMETALS,2012,25(6):1261-1268.
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