IR@PKUHSC  > 北京大学药学院
学科主题药学
Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex
Wei, Yong-Biao1,2,3; Yang, Xiao-Da1,2
关键词Bis ((5-hydroxy-4-oxo-4h-pyran-2-yl)Methyl Benzoatato) Oxovanadium (Iv) Diabetes Mellitus Blood Glucose Antioxidants
刊名BIOMETALS
2012-12-01
DOI10.1007/s10534-012-9587-x
25期:6页:1261-1268
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]AGENT ; BIS(ALPHA-FURANCARBOXYLATO)OXOVANADIUM(IV) ; RATS ; MICE
英文摘要

Vanadium complexes are potent hypoglycemic agents and of great potential for therapeutical treatment of diabetes. In the present work, a novel vanadium compound, bis ((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl benzoatato) oxovanadium (IV) (BBOV) has been synthesized. Treatment of STZ-induced diabetic rats with BBOV restored the blood glucose to normal level and ameliorated glucose tolerance. The hypoglycemic effect of BBOV is similar to that of bis (maltolato) oxovanadium but is less toxic in median lethal dose. Overall, the present work will provide useful information for further development of new anti-diabetic vanadium compounds.

语种英语
WOS记录号WOS:000310990900014
项目编号20971008 ; 2009ZX09502-006
资助机构NSFC ; Major New Medicine Projiect in Mega-projiects of Science Research of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49853
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Guangxi Med Univ, Sch Pharmaceut Sci, Nanning 530021, Guangxi, Peoples R China
推荐引用方式
GB/T 7714
Wei, Yong-Biao,Yang, Xiao-Da. Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex[J]. BIOMETALS,2012,25(6):1261-1268.
APA Wei, Yong-Biao,&Yang, Xiao-Da.(2012).Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex.BIOMETALS,25(6),1261-1268.
MLA Wei, Yong-Biao,et al."Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex".BIOMETALS 25.6(2012):1261-1268.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wei, Yong-Biao]的文章
[Yang, Xiao-Da]的文章
百度学术
百度学术中相似的文章
[Wei, Yong-Biao]的文章
[Yang, Xiao-Da]的文章
必应学术
必应学术中相似的文章
[Wei, Yong-Biao]的文章
[Yang, Xiao-Da]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。