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Prior to Foxp(3+) regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection
Wei, Lumin; Wang, Jingtong; Liu, Yulan
关键词Il-10-producing b Cells Helicobacter Pylori Regulatory t Cells
刊名PATHOGENS AND DISEASE
2014-10-01
DOI10.1111/2049-632X.12182
72期:1页:45-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; INFLAMMATORY RESPONSES ; ORAL TOLERANCE ; LUPUS MICE ; B10 CELLS ; GASTRITIS ; DISEASE ; CD4(+) ; IL-10 ; CD25(HIGH)
英文摘要

Regulatory T (Treg) cells play a critical role in Helicobacter pylori immune evasion and persistent infection. In addition to Treg cells, it is still unknown whether a newly defined B-cell subset, interleukin (IL)-10-producing B cells, is involved. Using a mouse model of H.pylori infection, we investigated the dynamic changes of IL-10-producing B cells and Foxp3(+) Treg cells in gastrointestinal mucosa, spleen and mesenteric lymph nodes following H.pylori infection. We observed that in addition to Foxp3(+) Treg cells, IL-10-producing B cells could also be induced after H.pylori infection and they expanded earlier than Foxp3(+) Treg cells did. Moreover, the regulatory immune responses induced by H.pylori were not limited to gastric mucosa. Our findings may provide new clues for further research on H.pylori immune evasion and diseases associated with H.pylori infection.

语种英语
WOS记录号WOS:000342770300009
项目编号81370515 ; RDB2012-21
资助机构National Natural Science Foundation of China ; Research and Development Foundation of Peking University People&prime ; s Hospital
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49854
专题北京大学第二临床医学院_老年科
北京大学第二临床医学院_消化科
作者单位Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
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Wei, Lumin,Wang, Jingtong,Liu, Yulan. Prior to Foxp(3+) regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection[J]. PATHOGENS AND DISEASE,2014,72(1):45-54.
APA Wei, Lumin,Wang, Jingtong,&Liu, Yulan.(2014).Prior to Foxp(3+) regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection.PATHOGENS AND DISEASE,72(1),45-54.
MLA Wei, Lumin,et al."Prior to Foxp(3+) regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection".PATHOGENS AND DISEASE 72.1(2014):45-54.
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