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学科主题: 临床医学
题名:
Prior to Foxp(3+) regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection
作者: Wei, Lumin; Wang, Jingtong; Liu, Yulan
关键词: IL-10-producing B cells ; Helicobacter pylori ; Regulatory T cells
刊名: PATHOGENS AND DISEASE
发表日期: 2014-10-01
DOI: 10.1111/2049-632X.12182
卷: 72, 期:1, 页:45-54
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]: Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]: EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; INFLAMMATORY RESPONSES ; ORAL TOLERANCE ; LUPUS MICE ; B10 CELLS ; GASTRITIS ; DISEASE ; CD4(+) ; IL-10 ; CD25(HIGH)
英文摘要:

Regulatory T (Treg) cells play a critical role in Helicobacter pylori immune evasion and persistent infection. In addition to Treg cells, it is still unknown whether a newly defined B-cell subset, interleukin (IL)-10-producing B cells, is involved. Using a mouse model of H.pylori infection, we investigated the dynamic changes of IL-10-producing B cells and Foxp3(+) Treg cells in gastrointestinal mucosa, spleen and mesenteric lymph nodes following H.pylori infection. We observed that in addition to Foxp3(+) Treg cells, IL-10-producing B cells could also be induced after H.pylori infection and they expanded earlier than Foxp3(+) Treg cells did. Moreover, the regulatory immune responses induced by H.pylori were not limited to gastric mucosa. Our findings may provide new clues for further research on H.pylori immune evasion and diseases associated with H.pylori infection.

语种: 英语
所属项目编号: 81370515 ; RDB2012-21
项目资助者: National Natural Science Foundation of China ; Research and Development Foundation of Peking University People&prime ; s Hospital
WOS记录号: WOS:000342770300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49854
Appears in Collections:北京大学第二临床医学院_消化内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China

Recommended Citation:
Wei, Lumin,Wang, Jingtong,Liu, Yulan. Prior to Foxp(3+) regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection[J]. PATHOGENS AND DISEASE,2014,72(1):45-54.
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