IR@PKUHSC  > 北京大学第三临床医学院  > 放射科
学科主题临床医学
Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury
Xu, Fangjingwei1; Han, Hongbin1; Yan, Junhao2; Chen, He1; He, Qingyuan1; Xu, Weiguo1; Zhu, Ning3; Zhang, Hong4; Zhou, Fugen4; Lee, Kejia5
关键词Blood Brain Barrier Stereotactic Delivery Magnetic Resonance Imaging Neuroprotection Brain Ischemia
刊名DRUG DELIVERY
2011-09-01
DOI10.3109/10717544.2011.589084
18期:7页:461-467
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者Project of New Century Excellent Talents in University of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation ; Project of New Century Excellent Talents in University of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CEREBRAL-ISCHEMIA ; CDP-CHOLINE ; BRAIN ; STROKE ; MECHANISMS ; DIFFUSION ; LIPOSOMES ; MRI
英文摘要

Limited penetration of neuroprotective drug citicoline into the central nervous system (CNS) by systemic administration led to poor efficiency. A novel method of stereotactic drug delivery was explored to make citicoline bypass the blood brain barrier (BBB) and take effect by direct contact with ischemic neurons. A permanent middle cerebral artery occlusion (pMCAO) model of rats was prepared. To get the optimal conditions for citicoline administration by the novel stereotactic delivery pathway, magnetic resonance imaging (MRI) tracer method was used, and a dose-dependent effect was given. Examinations of MRI, behavior evaluation, infarct volume assessment and histological staining were performed to evaluate the outcome. This MRI-guided stereotactic delivery of citicoline resulted in a notable reduction (>80%) in infarct size and a delayed ischemic injury in cortex 12 hours after onset of acute ischemia when compared with the systematic delivery. The improved neuroprotective efficiency was realized by a full distribution of citicoline in most of middle cerebral artery (MCA) territory and an adequate drug reaction in the involved areas of the brain. Brain lesions of treated rats by stereotactic delivery of citicoline were well predicted in the lateral ventricle and thalamus due to a limited drug deposition by MRI tracer method. Our study realized an improved neuroprotective efficiency of citicoline by stereotactic delivery, and an optimal therapeutic effect of this administration pathway can be achieved under MRI guidance.

语种英语
所属项目编号NCET-05-0019 ; 30972811 ; 7093137
资助者Project of New Century Excellent Talents in University of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation ; Project of New Century Excellent Talents in University of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation
WOS记录号WOS:000294967700001
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49856
专题北京大学第三临床医学院_放射科
作者单位1.Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100191, Peoples R China
4.Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
5.Max Planck Inst Radio Astron, D-53121 Bonn, Germany
推荐引用方式
GB/T 7714
Xu, Fangjingwei,Han, Hongbin,Yan, Junhao,et al. Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury[J]. DRUG DELIVERY,2011,18(7):461-467.
APA Xu, Fangjingwei.,Han, Hongbin.,Yan, Junhao.,Chen, He.,He, Qingyuan.,...&Lee, Kejia.(2011).Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury.DRUG DELIVERY,18(7),461-467.
MLA Xu, Fangjingwei,et al."Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury".DRUG DELIVERY 18.7(2011):461-467.
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