北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 放射科  > 期刊论文
学科主题: 临床医学
题名:
Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury
作者: Xu, Fangjingwei1; Han, Hongbin1; Yan, Junhao2; Chen, He1; He, Qingyuan1; Xu, Weiguo1; Zhu, Ning3; Zhang, Hong4; Zhou, Fugen4; Lee, Kejia5
关键词: Blood brain barrier ; stereotactic delivery ; magnetic resonance imaging ; neuroprotection ; brain ischemia
刊名: DRUG DELIVERY
发表日期: 2011-09-01
DOI: 10.3109/10717544.2011.589084
卷: 18, 期:7, 页:461-467
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CEREBRAL-ISCHEMIA ; CDP-CHOLINE ; BRAIN ; STROKE ; MECHANISMS ; DIFFUSION ; LIPOSOMES ; MRI
英文摘要:

Limited penetration of neuroprotective drug citicoline into the central nervous system (CNS) by systemic administration led to poor efficiency. A novel method of stereotactic drug delivery was explored to make citicoline bypass the blood brain barrier (BBB) and take effect by direct contact with ischemic neurons. A permanent middle cerebral artery occlusion (pMCAO) model of rats was prepared. To get the optimal conditions for citicoline administration by the novel stereotactic delivery pathway, magnetic resonance imaging (MRI) tracer method was used, and a dose-dependent effect was given. Examinations of MRI, behavior evaluation, infarct volume assessment and histological staining were performed to evaluate the outcome. This MRI-guided stereotactic delivery of citicoline resulted in a notable reduction (>80%) in infarct size and a delayed ischemic injury in cortex 12 hours after onset of acute ischemia when compared with the systematic delivery. The improved neuroprotective efficiency was realized by a full distribution of citicoline in most of middle cerebral artery (MCA) territory and an adequate drug reaction in the involved areas of the brain. Brain lesions of treated rats by stereotactic delivery of citicoline were well predicted in the lateral ventricle and thalamus due to a limited drug deposition by MRI tracer method. Our study realized an improved neuroprotective efficiency of citicoline by stereotactic delivery, and an optimal therapeutic effect of this administration pathway can be achieved under MRI guidance.

语种: 英语
所属项目编号: NCET-05-0019 ; 30972811 ; 7093137
项目资助者: Project of New Century Excellent Talents in University of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000294967700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49856
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100191, Peoples R China
4.Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
5.Max Planck Inst Radio Astron, D-53121 Bonn, Germany

Recommended Citation:
Xu, Fangjingwei,Han, Hongbin,Yan, Junhao,et al. Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury[J]. DRUG DELIVERY,2011,18(7):461-467.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Fangjingwei]'s Articles
[Han, Hongbin]'s Articles
[Yan, Junhao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Fangjingwei]‘s Articles
[Han, Hongbin]‘s Articles
[Yan, Junhao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace