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Investigations of taxoids by electrospray and atmospheric pressure chemical ionization with tandem mass spectrometry
Ye, M; Guo, DA
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2005
DOI10.1002/rcm.1839
19期:6页:818-824
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]ONLINE IDENTIFICATION ; CONSTITUENTS ; FRAGMENTATION ; EXTRACTS
英文摘要

The fragmentation behavior of taxoids was studied using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources with multi-stage tandem mass spectrometry. In the positive ion mode taxoids gave prominent [M+Na](+) and [M+K](+) ions with the ESI source, and [M+NH4](+) or [M+H](+) ions with the APCI source. The MS/MS fragmentations of ions produced by APCI and ESI sources were very similar. For both sources, the presence of cinnamoyl or benzoyl groups could be characterized by initial losses of 148 or 122 u, respectively, from molecular adduct ions. However, the elimination of cinnamic acid was relatively difficult for the molecular adduct ions formed by APCI, and was comparable in importance to the loss of acetic acid. The other fragments involved losses of CH2CO, CO, and H2O. The 5/7/6 type taxoids underwent characteristic losses of 58 or 118 u from ions produced by both APCI and ESI sources. The fragmentation behavior was remarkably influenced by substitution locations. The elimination of the C-10 benzoyl group was usually the first fragmentation step, while that of the C-2 benzoyl group was relatively difficult. The acetoxyl group at C-7 was more active than those at C-2, C-9, and C-10, which in turn were more active than that at C-4. These fragmentation rules could facilitate the rapid screening and structural characterization of taxoids in plant extracts by high-performance liquid chromatography/mass spectrometry (HPLC/MS). Copyright (c) 2005 John Wiley T Sons, Ltd.

语种英语
WOS记录号WOS:000227519500011
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49858
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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Ye, M,Guo, DA. Investigations of taxoids by electrospray and atmospheric pressure chemical ionization with tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2005,19(6):818-824.
APA Ye, M,&Guo, DA.(2005).Investigations of taxoids by electrospray and atmospheric pressure chemical ionization with tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,19(6),818-824.
MLA Ye, M,et al."Investigations of taxoids by electrospray and atmospheric pressure chemical ionization with tandem mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 19.6(2005):818-824.
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