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学科主题: 临床医学
题名:
Tetracycline- and Furazolidone-containing Quadruple Regimen as Rescue Treatment for Helicobacter pylori Infection: A Single Center Retrospective Study
作者: Zhang, Yuemiao1; Gao, Wen2; Cheng, Hong2; Zhang, Xuezhi1; Hu, Fulian2
关键词: Helicobacter pylori ; tetracycline ; furazolidone ; efficacy ; side effects
刊名: HELICOBACTER
发表日期: 2014-10-01
DOI: 10.1111/hel.12143
卷: 19, 期:5, 页:382-386
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Microbiology
研究领域[WOS]: Gastroenterology & Hepatology ; Microbiology
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; CONSENSUS REPORT ; GASTRIC-CANCER ; ERADICATION ; THERAPY ; CHINA ; RESISTANCE ; BISMUTH ; METAANALYSIS ; AMOXICILLIN
英文摘要:

Background and ObjectiveEradication rate of Helicobacter pylori decreases worldwide, while antibiotics resistance rates of H.pylori increase rapidly in recent years. In most cases, H.pylori would be resistant to clarithromycin, metronidazole, and quinolone if these antibiotics had been used as component of eradication regimen. H.pylori strains resistant to both tetracycline and furazolidone are rare. The aim of our study was to evaluate efficacy and side effects of tetracycline- and furazolidone-containing quadruple regimen as rescue treatment.

MethodsPatients with H.pylori infection given RTFB (rabeprazole 20mg b.i.d. + tetracycline 750mg b.i.d. +furazolidone 100mg b.i.d. + colloidal bismuth subcitrate 200mg b.i.d.) regimen for 14days as rescue treatment were enrolled in this retrospective study. Eradication status was evaluated by C-13-urea breath test, and side effects were collected.

ResultsOne hundred and nine patients were enrolled. The intention-to-treat eradication rate was 91.74% (100 of 109) and 95.24% (100 of 105) per protocol analysis. Side effects including fever, palpitation, and skin rash occurred in 35 patients.

ConclusionsThe 14-day tetracycline- and furazolidone-containing quadruple regimen can achieve a relatively high eradication rate as rescue treatment. Some side effects including fever may occur during the treatment.

语种: 英语
WOS记录号: WOS:000342989000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49869
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Integrated TCM & Western Med, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Yuemiao,Gao, Wen,Cheng, Hong,et al. Tetracycline- and Furazolidone-containing Quadruple Regimen as Rescue Treatment for Helicobacter pylori Infection: A Single Center Retrospective Study[J]. HELICOBACTER,2014,19(5):382-386.
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