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学科主题: 临床医学
题名:
The relationship between serum anti-Mullerian hormone levels and the follicular arrest for women with polycystic ovary syndrome
作者: Li, Jian1,2; Li, Rong1; Yu, Hua2; Zhao, Shuyun1; Yu, Yang1; Qiao, Jie1
关键词: Anti-Mullerian hormone ; follicular arrest ; LH ; polycystic ovary syndrome ; testosterone
刊名: SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
发表日期: 2015-04-01
DOI: 10.3109/19396368.2014.973123
卷: 61, 期:2, 页:103-109
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Reproductive Biology
研究领域[WOS]: Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]: RIBONUCLEIC-ACID EXPRESSION ; STIMULATING-HORMONE ; MENSTRUAL-CYCLE ; AMH LEVEL ; HYPERSTIMULATION ; DYNAMICS ; FOLLICULOGENESIS ; HYPERANDROGENISM ; ANOVULATION ; DEFINITION
英文摘要:

The aim of this study was to ascertain whether higher levels of serum anti-Mullerian hormone (AMH) are associated with the ovarian follicular arrest in women with polycystic ovary syndrome (PCOS). This prospective study compared AMH levels between serum and dominant follicular fluid (FF) in ovulatory polycystic ovary (PCO) women and anovulatory (menstrual cycle >= 60 days.) PCOS women. All 102 women provided a baseline hormone profile and underwent controlled ovarian hyperstimulation (COH). The anovulatory PCO women had a similar body mass index (BMI), antral follicle count (AFC), and baseline serum AMH levels as the ovulatory PCO women except that their median luteinizing hormone (LH; 10.0 mIU/ml), testosterone (T) (0.61 ng/l), and androstenedione (A) (3.47 ng/l) levels were significantly higher than ovulatory PCO women (4.9 mIU/m; 0.43 ng/l and 2.09 ng/l, respectively). The ovarian response to gonadotropin stimulation during COH including serum AMH on the day of HCG administration and dominant FF AMH at 36 hours after HCG administration, total follicle stimulating hormone (FSH) dose administrated, peak E-2, (estrogen) levels and number of occytes retrieved were all similar between women with anovulatory and ovulatory PCO. Using multiple regression analysis it was found that an important independent determinant affecting AMH was AFC, as opposed to LH and T. Logistic regression analysis showed that the two most important factors affecting ovulation were serum LH and T, whereas serum AMH and AFC were not selected for inclusion in the model. The reduction in AMH during COH occurs as a consequence of dominant follicles with a corresponding reduction in small antral follicle number. Elevated serum AMH levels in PCO women seem to be related only to follicular excess and not follicular arrest.

语种: 英语
所属项目编号: 2012BAI32B01 ; 81300482 ; 81170538 ; 7142166
项目资助者: National "Twelfth Five-Year&prime ; &prime ; Plan for Science &amp ; Technology Support ; National Science Fund ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000351609300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49870
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
2.Dalian Obstet & Gynecol Hosp 1, Ctr Reprod Med, Dalian, Peoples R China

Recommended Citation:
Li, Jian,Li, Rong,Yu, Hua,et al. The relationship between serum anti-Mullerian hormone levels and the follicular arrest for women with polycystic ovary syndrome[J]. SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE,2015,61(2):103-109.
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