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学科主题: 药学
题名:
Pharmacokinetics and Tissue Distribution of Dual-Targeting Daunorubicin Liposomes in Mice
作者: Ying, Xue1,2,3,4; Wen, He1,2; Yao, Hong-Juan1,2; Zhang, Yan1,2; Tian, Wei1,2; Zhang, Liang1,2; Ju, Rui-Jun1,2; Wang, Xiao-Xing1,2; Yu, Yang1,2; Lu, Wan-Liang1,2
关键词: Dual-targeting daunorubicin liposomes ; Pharmacokinetics ; Tissue distribution ; HPLC
刊名: PHARMACOLOGY
发表日期: 2011
DOI: 10.1159/000323222
卷: 87, 期:1-2, 页:105-114
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CLEARANCE ABC PHENOMENON ; IN-VIVO ; PEGYLATED LIPOSOMES ; EFFICACY ; DRUG ; DERIVATIVES ; DOXORUBICIN ; MECHANISMS
英文摘要:

Background:To circumvent the problem of transporting anticancer drugs across the blood-brain barrier (BBB) to target brain tumors, we have previously developed dual-targeting daunorubicin liposomes modified with 4-aminophenyl-alpha-D-manno-pyranoside and transferrin molecules. The objective of the present study was to evaluate the pharmacokinetics and distribution of daunorubicin after intravenous administration of dual-targeting daunorubicin liposomes. Methods: We evaluated pharmacological parameters in normal Kun-Ming mice. Drug concentrations in plasma, heart, spleen, lung, kidney and brain were measured using HPLC-UV. Results: The plasma drug concentration-time profile of the daunorubicin dual-targeting liposomes decreased more slowly than free daunorubicin in the initial phase and maintained higher drug levels in the terminal phase, resulting in longer blood exposure to daunorubicin liposomes compared with the free drug. Daunorubicin levels were lower in heart tissue and significantly higher in brain tissue after administration of the dual-targeting liposomes compared with the free drug. Daunorubicin was detected at varying levels in the liver, spleen, lung and kidney tissues. Conclusion: Our results indicate that dual-targeting daunorubicin liposomes improve the daunorubicin blood circulation time and show an enhanced drug transport potential across the BBB. Copyright (C) 2011 S. Karger AG, Basel

语种: 英语
所属项目编号: 2007CB935801 ; 20772664 ; 7091005 ; RCZX201029
项目资助者: National Basic Research Program of China (973 program) ; National Science Foundation of China ; Beijing Natural Science Foundation ; Scientific Research Foundation of Shihezi University
WOS记录号: WOS:000287560600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49875
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Shihezi Univ, Key Lab Phytomed Resources & Modernizat Tradit Ch, Shihezi, Peoples R China
4.Shihezi Univ, Sch Pharmaceut Sci, Shihezi, Peoples R China

Recommended Citation:
Ying, Xue,Wen, He,Yao, Hong-Juan,et al. Pharmacokinetics and Tissue Distribution of Dual-Targeting Daunorubicin Liposomes in Mice[J]. PHARMACOLOGY,2011,87(1-2):105-114.
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