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学科主题: 临床医学
题名:
Impact of nitric oxide on adrenomedullin- and proadrenomedullin N-terminal 20 peptide-induced cardiac responses: action by alone and combined administration
作者: Yang, JH1; Zhu, MJ1; Fu, FY1; Tang, CS1; Li, JX1
关键词: adrenomedullin ; proadrenomedullin N-terminal 20 peptide ; N-omega-nitro-L-arginine methyl ester ; isolated rat heart
刊名: PEPTIDES
发表日期: 2003-12-01
DOI: 10.1016/j.peptides.2003.10.014
卷: 24, 期:12, 页:1963-1969
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: MICROVASCULAR ENDOTHELIAL-CELLS ; HUMAN HEART-FAILURE ; VENTRICULAR MYOCYTES ; SYNTHASE ; RAT ; PAMP ; SECRETION ; PLASMA ; IDENTIFICATION ; 20-PEPTIDE
英文摘要:

The cardiac effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) as well as the possible signaling pathways were investigated. In the isolated perfused rat heart, infusion of AM (10(-11) to 10(-8) M) and PAMP (10(-11) to 10(-8) M) for 10 min, alone or in combination, induced concentration-dependent decreases in the left ventricular pressure (LVP), LVP +/- dp/dt(max) of the hearts. The effects were attenuated by N-omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthase. ADM and PAMP alone or in combinations increased the coronary fluid (CF), which could be antagonized by L-NAME. Pretreatment of H89, an inhibitor of protein kinase A (PKA), failed to alter the AM- or PAMP-induced decreases in LVP and LVP +/- dp/dt(max) but further promoted the AM or PAMP increased CF. The cAMP content in left cardiac ventricle was increased significantly by ADM infusions but not by PAMP. There was no statistical difference in cAMP contents with ADM administrated alone from those combined with ADM and PAMP. In conclusion, this study reveals that ADM and PAMP infused alone or in combinations inhibited the function of rat hearts in vitro, which may be partly involved with the NOS/NO pathway, rather than cAMP/PKA. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000189091600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49879
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China

Recommended Citation:
Yang, JH,Zhu, MJ,Fu, FY,et al. Impact of nitric oxide on adrenomedullin- and proadrenomedullin N-terminal 20 peptide-induced cardiac responses: action by alone and combined administration[J]. PEPTIDES,2003,24(12):1963-1969.
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