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学科主题临床医学
Activation of NF-kappa B in bronchial epithelial cells from children with asthma
Zhao, SY1; Qi, Y1; Liu, XH1; Jiang, QB1; Liu, SY1; Jiang, Y1; Jiang, ZF1
关键词Nuclear Factor-kappa b Epithelial Cells Asthma
刊名CHINESE MEDICAL JOURNAL
2001-09-01
114期:9页:909-911
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]TRANSCRIPTION
英文摘要

Objectives To determine whether nuclear factor-kappaB (NF-kappaB) is activated in epithelial cells from children with asthma and to understand the role of NF-kappaB in airway inflammation in asthma.

Methods Bronchial mucosa specimens were obtained from 9 children with asthma and 6 control subjects. NF-kappaB expression in epithelial cells were detected by Immunohistochemical examination, and NF-kappaB-DNA binding was measured by electrophoretic mobility shift assay (EMSA).

Results Nuclear expression of NF-kappaB in epithelia[ cells was observed in the 9 asthmatic children. NF-kappaB-DNA binding was found in 4 asthmatic children (EMSA was performed in 6 asthmatic children). In contrast, both nuclear expression and NF-kappaB-DNA binding were absent in the 6 control subjects.

Conclusion These results indicated that NF-epsilonB is activated in epithelial cells from asthmatic children and the NF-kappaB activation may be the basis for the increased expression of many inflammatory genes and for airway inflammation in asthma.

语种英语
WOS记录号WOS:000171143400004
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49890
专题北京大学第一临床医学院_中心实验室
作者单位1.Beijing Inst Pediat Res, Pulm Funct Lab, Beijing 100045, Peoples R China
2.Beijing Univ, Clin Hosp 1, Cent Lab, Beijing 100034, Peoples R China
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GB/T 7714
Zhao, SY,Qi, Y,Liu, XH,et al. Activation of NF-kappa B in bronchial epithelial cells from children with asthma[J]. CHINESE MEDICAL JOURNAL,2001,114(9):909-911.
APA Zhao, SY.,Qi, Y.,Liu, XH.,Jiang, QB.,Liu, SY.,...&Jiang, ZF.(2001).Activation of NF-kappa B in bronchial epithelial cells from children with asthma.CHINESE MEDICAL JOURNAL,114(9),909-911.
MLA Zhao, SY,et al."Activation of NF-kappa B in bronchial epithelial cells from children with asthma".CHINESE MEDICAL JOURNAL 114.9(2001):909-911.
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