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学科主题: 临床医学
题名:
Activation of NF-kappa B in bronchial epithelial cells from children with asthma
作者: Zhao, SY1; Qi, Y1; Liu, XH1; Jiang, QB1; Liu, SY1; Jiang, Y1; Jiang, ZF1
关键词: nuclear factor-kappa B ; epithelial cells ; asthma
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-09-01
卷: 114, 期:9, 页:909-911
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: TRANSCRIPTION
英文摘要:

Objectives To determine whether nuclear factor-kappaB (NF-kappaB) is activated in epithelial cells from children with asthma and to understand the role of NF-kappaB in airway inflammation in asthma.

Methods Bronchial mucosa specimens were obtained from 9 children with asthma and 6 control subjects. NF-kappaB expression in epithelial cells were detected by Immunohistochemical examination, and NF-kappaB-DNA binding was measured by electrophoretic mobility shift assay (EMSA).

Results Nuclear expression of NF-kappaB in epithelia[ cells was observed in the 9 asthmatic children. NF-kappaB-DNA binding was found in 4 asthmatic children (EMSA was performed in 6 asthmatic children). In contrast, both nuclear expression and NF-kappaB-DNA binding were absent in the 6 control subjects.

Conclusion These results indicated that NF-epsilonB is activated in epithelial cells from asthmatic children and the NF-kappaB activation may be the basis for the increased expression of many inflammatory genes and for airway inflammation in asthma.

语种: 英语
WOS记录号: WOS:000171143400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49890
Appears in Collections:北京大学第一临床医学院_中心实验室_期刊论文

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作者单位: 1.Beijing Inst Pediat Res, Pulm Funct Lab, Beijing 100045, Peoples R China
2.Beijing Univ, Clin Hosp 1, Cent Lab, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, SY,Qi, Y,Liu, XH,et al. Activation of NF-kappa B in bronchial epithelial cells from children with asthma[J]. CHINESE MEDICAL JOURNAL,2001,114(9):909-911.
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