北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 中心实验室  > 期刊论文
学科主题: 临床医学
题名:
Activation of NF-kappa B in bronchial epithelial cells from children with asthma
作者: Zhao, SY1; Qi, Y1; Liu, XH1; Jiang, QB1; Liu, SY1; Jiang, Y1; Jiang, ZF1
关键词: nuclear factor-kappa B ; epithelial cells ; asthma
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-09-01
卷: 114, 期:9, 页:909-911
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: TRANSCRIPTION
英文摘要:

Objectives To determine whether nuclear factor-kappaB (NF-kappaB) is activated in epithelial cells from children with asthma and to understand the role of NF-kappaB in airway inflammation in asthma.

Methods Bronchial mucosa specimens were obtained from 9 children with asthma and 6 control subjects. NF-kappaB expression in epithelial cells were detected by Immunohistochemical examination, and NF-kappaB-DNA binding was measured by electrophoretic mobility shift assay (EMSA).

Results Nuclear expression of NF-kappaB in epithelia[ cells was observed in the 9 asthmatic children. NF-kappaB-DNA binding was found in 4 asthmatic children (EMSA was performed in 6 asthmatic children). In contrast, both nuclear expression and NF-kappaB-DNA binding were absent in the 6 control subjects.

Conclusion These results indicated that NF-epsilonB is activated in epithelial cells from asthmatic children and the NF-kappaB activation may be the basis for the increased expression of many inflammatory genes and for airway inflammation in asthma.

语种: 英语
WOS记录号: WOS:000171143400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49890
Appears in Collections:北京大学第一临床医学院_中心实验室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Inst Pediat Res, Pulm Funct Lab, Beijing 100045, Peoples R China
2.Beijing Univ, Clin Hosp 1, Cent Lab, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, SY,Qi, Y,Liu, XH,et al. Activation of NF-kappa B in bronchial epithelial cells from children with asthma[J]. CHINESE MEDICAL JOURNAL,2001,114(9):909-911.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, SY]'s Articles
[Qi, Y]'s Articles
[Liu, XH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, SY]‘s Articles
[Qi, Y]‘s Articles
[Liu, XH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace