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学科主题临床医学
Independent prognostic factors for initial intravesical recurrence after laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma
Liu, Yuqing; Lu, Jian; Hong, Kai; Huang, Yi; Ma, Lulin
关键词Laparoscopic Surgery Transitional Cell Carcinoma Bladder Cancer Recurrence Immunosuppression
刊名UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
2014-02-01
DOI10.1016/j.urolonc.2013.02.018
32期:2页:146-152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Urology & Nephrology
研究领域[WOS]Oncology ; Urology & Nephrology
关键词[WOS]TRANSITIONAL-CELL CARCINOMA ; BLADDER-CANCER ; TRANSPLANT RECIPIENTS ; SURGICAL-MANAGEMENT ; RISK-FACTORS ; OUTCOMES ; TUMORS
英文摘要

Objective: To elucidate clinicopathologic independent prognostic factors for intravesical recurrence after laparoscopic nephroureterectomy for primary upper urinary tract urothelial carcinoma (UUT-UC).

Methods and materials: This study included 212 consecutive patients clinically diagnosed as localized UUT-UC and treated by retroperitoneal laparoscopic nephroureterectomy between January 2002 and October 2010, after exclusion of those with a previous or concurrent history of bladder cancer. The clinicopathologic features, risk factors, and intravesical recurrence free survival were analyzed using the Kaplan-Meier method. Univariate and multivariate analyses by Cox proportional hazards regression model was used to identify independent risk factors for intravesical tumor recurrence.

Results: Of the patients, 64/212 (30.2%) developed subsequent intravesical recurrence during a median follow-up period of 39 months (range 7-78 months). Among them, 56/64 (87.5%) developed recurrent bladder cancer within 2 years after the surgery for UUT-UC, and the median interval between surgery and intravesical recurrence was 14 months (range 7-51 months). Multifocal tumors, renal insufficiency, and immunosuppression were determined as risk factors for intravesical recurrence by univariate analysis. However, by multivariate analyses, multifocality (hazard ratio = 2.060, P = 0.006) and immunosuppression (hazard ratio = 1.915, P = 0.037) were identified as independent predictors for the development of recurrent bladder cancer.

Conclusions: The incidence of intravesical recurrence after laparoscopic nephroureterectomy for UUT-UC is high, and most subsequent bladder cancers recur within 2 years after surgery. Tumor multifocality and immunosuppression are significant independent risk factors in developing initial intravesical recurrence after laparoscopic surgery for primary UUT-UC. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000330500300012
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49896
专题北京大学第三临床医学院_泌尿外科
作者单位Peking Univ, Hosp 3, Dept Urol, Beijing 100871, Peoples R China
推荐引用方式
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Liu, Yuqing,Lu, Jian,Hong, Kai,et al. Independent prognostic factors for initial intravesical recurrence after laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma[J]. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS,2014,32(2):146-152.
APA Liu, Yuqing,Lu, Jian,Hong, Kai,Huang, Yi,&Ma, Lulin.(2014).Independent prognostic factors for initial intravesical recurrence after laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma.UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS,32(2),146-152.
MLA Liu, Yuqing,et al."Independent prognostic factors for initial intravesical recurrence after laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma".UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32.2(2014):146-152.
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