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学科主题: 基础医学
题名:
Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics
作者: Jing, Lijia10; Shi, Jiyun7,8; Fan, Di7; Li, Yaqian9; Liu, Renfa6; Dai, Zhifei6; Wang, Fan7,8; Tian, Jie9; Jing, Lijia15; Shi, Jiyun12,13; Fan, Di12; Li, Yaqian14; Liu, Renfa11; Dai, Zhifei11; Wang, Fan12,13; Tian, Jie14
关键词: cerasome ; indocyanine green ; multimodal imaging ; photothermal therapy ; nanotheranostics
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015-10-07
DOI: 10.1021/acsami.5b07856
卷: 7, 期:39, 页:22095-22105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: MESOPOROUS SILICA NANOPARTICLES ; TRIGGERED DRUG-RELEASE ; PHOTOTHERMAL THERAPY ; IN-VIVO ; CONTRAST AGENTS ; GOLD NANOCAGES ; FLUORESCENCE ; MICROCAPSULES ; NANOPROBES ; EFFICACY
英文摘要:

This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanol-amine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG(2000)-DOTA), followed by chelating radioisotope of Lu-177. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile. Both fluorescence and nuclear imaging showed that such agent could selectively accumulate in tumor site after intravenous injection of the cerasome agent into Lewis lung carcinoma tumor bearing mice, resulting in efficient photothermal ablation of tumor through a one-time NIR laser irradiation at the best time window. The ability to track the uptake of cerasomes on a whole body basis could provide researchers with an excellent tool for developing cerasome-based drug delivery agents, especially the strategy of labeling cerasomes with theranostic radionuclide Lu-177, enabling the ability of the Lu-177-labeled cerasomes for radionuclide cancer therapy and even the combined therapy.

语种: 英语
所属项目编号: 81230036 ; 2013AA032201 ; 21273014 ; 81321003 ; 81420108019 ; 81125011 ; 81225011
项目资助者: State Key Program of the National Natural Science of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation for Distinguished Young Scholars ; Foundation for Innovative Research Groups
WOS记录号: WOS:000362628900058
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49898
Appears in Collections:基础医学院_放射医学教研室_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Interdisciplinary Lab, Beijing 100101, Peoples R China
4.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
5.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
6.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
7.Peking Univ, Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China
8.Chinese Acad Sci, Inst Biophys, Interdisciplinary Lab, Beijing 100101, Peoples R China
9.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
10.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
11.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
12.Peking Univ, Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China
13.Chinese Acad Sci, Inst Biophys, Interdisciplinary Lab, Beijing 100101, Peoples R China
14.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
15.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China

Recommended Citation:
Jing, Lijia,Shi, Jiyun,Fan, Di,et al. Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(39):22095-22105.
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