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学科主题临床医学
Minocycline Inhibition of Photoreceptor Degeneration
Yang, Liu2,3; Kim, Joon-Hyun3; Kovacs, Kyle D.1; Arroyo, Jorge G.1; Chen, Dong F.3
刊名ARCHIVES OF OPHTHALMOLOGY
2009-11-01
127期:11页:1475-1480
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]CYTOCHROME-C RELEASE ; RETINAL-DETACHMENT ; NEUROPROTECTION ; MICE ; ACTIVATION ; APOPTOSIS ; INJURY ; DAMAGE ; BRAIN
英文摘要

Objective: To determine whether systemic minocycline can protect photoreceptors in experimental retinal detachment (RD).

Methods: Retinal detachment was induced in mice by subretinal injection of sodium hyaluronate, 1.4%. In 1 experiment, mice received daily injections of minocycline (group 1) or saline (group 2). In a second experiment, mice were treated with minocycline or saline beginning 24 hours prior, immediately after, or 24 hours after experimental RD. In both experiments, photoreceptor cell survival and apoptosis were assessed by immunohistochemistry with primary antibodies against photoreceptor cell markers, rod rhodopsin, and cone opsin, and by terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling.

Results: Photoreceptor cell apoptosis was detected at day 1 after experimental RD, with apoptotic cells peaking in number at day 3 and dropping by day 7. Treatment with minocycline significantly reduced the number of apoptotic photoreceptor cells associated with RD when given 24 hours before or even 24 hours after RD.

Conclusions: Our data suggest that minocycline may be useful in the treatment of photoreceptor degeneration associated with RD, even when given up to 24 hours afterRD.

语种英语
WOS记录号WOS:000271583700009
项目编号30571987 ; K-23
资助机构Natural Science Foundation of China ; National Institutes of Health ; Mentored Physician Training ; Department of Defense, the Massachusetts Lions Eye Research Fund ; Research to Prevent Blindness ; Schepens Eye Research Institute ; Massachusetts Eye and Ear Infirmary of Harvard Medical School
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49903
专题北京大学第一临床医学院_眼科
作者单位1.Beth Israel Deaconess Med Ctr, Div Ophthalmol, Retina Serv, Dept Ophthalmol, Boston, MA 02215 USA
2.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing 100871, Peoples R China
3.Harvard Univ, Sch Med, Dept Ophthalmol, Schepens Eye Res Inst, Boston, MA USA
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GB/T 7714
Yang, Liu,Kim, Joon-Hyun,Kovacs, Kyle D.,et al. Minocycline Inhibition of Photoreceptor Degeneration[J]. ARCHIVES OF OPHTHALMOLOGY,2009,127(11):1475-1480.
APA Yang, Liu,Kim, Joon-Hyun,Kovacs, Kyle D.,Arroyo, Jorge G.,&Chen, Dong F..(2009).Minocycline Inhibition of Photoreceptor Degeneration.ARCHIVES OF OPHTHALMOLOGY,127(11),1475-1480.
MLA Yang, Liu,et al."Minocycline Inhibition of Photoreceptor Degeneration".ARCHIVES OF OPHTHALMOLOGY 127.11(2009):1475-1480.
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