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学科主题: 临床医学
题名:
Minocycline Inhibition of Photoreceptor Degeneration
作者: Yang, Liu2,3; Kim, Joon-Hyun3; Kovacs, Kyle D.1; Arroyo, Jorge G.1; Chen, Dong F.3
刊名: ARCHIVES OF OPHTHALMOLOGY
发表日期: 2009-11-01
卷: 127, 期:11, 页:1475-1480
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: CYTOCHROME-C RELEASE ; RETINAL-DETACHMENT ; NEUROPROTECTION ; MICE ; ACTIVATION ; APOPTOSIS ; INJURY ; DAMAGE ; BRAIN
英文摘要:

Objective: To determine whether systemic minocycline can protect photoreceptors in experimental retinal detachment (RD).

Methods: Retinal detachment was induced in mice by subretinal injection of sodium hyaluronate, 1.4%. In 1 experiment, mice received daily injections of minocycline (group 1) or saline (group 2). In a second experiment, mice were treated with minocycline or saline beginning 24 hours prior, immediately after, or 24 hours after experimental RD. In both experiments, photoreceptor cell survival and apoptosis were assessed by immunohistochemistry with primary antibodies against photoreceptor cell markers, rod rhodopsin, and cone opsin, and by terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling.

Results: Photoreceptor cell apoptosis was detected at day 1 after experimental RD, with apoptotic cells peaking in number at day 3 and dropping by day 7. Treatment with minocycline significantly reduced the number of apoptotic photoreceptor cells associated with RD when given 24 hours before or even 24 hours after RD.

Conclusions: Our data suggest that minocycline may be useful in the treatment of photoreceptor degeneration associated with RD, even when given up to 24 hours afterRD.

语种: 英语
所属项目编号: 30571987 ; K-23
项目资助者: Natural Science Foundation of China ; National Institutes of Health ; Mentored Physician Training ; Department of Defense, the Massachusetts Lions Eye Research Fund ; Research to Prevent Blindness ; Schepens Eye Research Institute ; Massachusetts Eye and Ear Infirmary of Harvard Medical School
WOS记录号: WOS:000271583700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49903
Appears in Collections:北京大学第一临床医学院_眼科_期刊论文

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作者单位: 1.Beth Israel Deaconess Med Ctr, Div Ophthalmol, Retina Serv, Dept Ophthalmol, Boston, MA 02215 USA
2.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing 100871, Peoples R China
3.Harvard Univ, Sch Med, Dept Ophthalmol, Schepens Eye Res Inst, Boston, MA USA

Recommended Citation:
Yang, Liu,Kim, Joon-Hyun,Kovacs, Kyle D.,et al. Minocycline Inhibition of Photoreceptor Degeneration[J]. ARCHIVES OF OPHTHALMOLOGY,2009,127(11):1475-1480.
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