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学科主题临床医学
Hydrogen sulfide protects rat lung from ischemia-reperfusion injury
Fu, Zhifang1; Liu, Xinmin1; Geng, Bin2; Fang, Liping1; Tang, Chaoshu2
关键词Hydrogen Sulfide Lung Ischemia-reperfusion Injury Oxidative Stress
刊名LIFE SCIENCES
2008-06-06
DOI10.1016/j.lfs.2008.04.005
82期:23-24页:1196-1202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]OXIDATIVE STRESS ; H2S ; ACTIVATION ; CARDIOMYOCYTES ; PRESERVATION ; INFLAMMATION ; INHIBITOR ; SCAVENGER ; MOUSE
英文摘要

Recent studies have indicated that hydrogen sulfide (H2S) is capable of modulating many physiological processes, which prompted us to investigate the potential of H2S as a lung protective agent. To explore changes in the generation of endogenous H2S and the role of H2S in the pathogenesis of pulmonary ischemia-reperfusion (I/R) injury in rats, we built an isolated rat lung I/R model. Lungs were subjected to 45 min ischemia followed by reperfusion (45 min) and were pretreated with H2S (50 mu mol/l or 100 mu mol/l) or an irreversible inhibitor of cystathionine-gamma-lyase (CSE), propargylglycine (PPG; 2 mmol/l). We examined indices of lung injury: lung histological change, perfusion flow rate, ratio of lung wet weight to dry weight (w/d), and lung compliance. H2S content and CSE protein expression in lung tissues were measured. Malondialdehyde (MDA) content, activities of superoxide dismutase (SOD) and catalase (CAT), and restraint of superoxide anion (O-2(-)) production in lung tissues were measured to reflect oxidative stress. In the current study, we demonstrated that H2S content and CSE activity in lungs after I/R were significantly higher than those in the control group. Preperfusion with H2S attenuated the lung I/R injury while preperfusion with PPG aggravated the lung I/R injury. H2S preperfusion reduced I/R-induced MDA production and potentiated SOD and CAT activities and the restraint of O-2(-) production in the lungs under I/R, which attenuated lung oxidative injury. These findings suggest that endogenous CSE/H2S pathway might be involved in the pathogenesis of lung I/R injury and that administration of H2S might be of clinical benefit in lung I/R injury. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000256749000010
引用统计
被引频次:84[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49910
专题北京大学第一临床医学院_老年病内科
作者单位1.Peking Univ, First Hosp, Dept Geriatr, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Fu, Zhifang,Liu, Xinmin,Geng, Bin,et al. Hydrogen sulfide protects rat lung from ischemia-reperfusion injury[J]. LIFE SCIENCES,2008,82(23-24):1196-1202.
APA Fu, Zhifang,Liu, Xinmin,Geng, Bin,Fang, Liping,&Tang, Chaoshu.(2008).Hydrogen sulfide protects rat lung from ischemia-reperfusion injury.LIFE SCIENCES,82(23-24),1196-1202.
MLA Fu, Zhifang,et al."Hydrogen sulfide protects rat lung from ischemia-reperfusion injury".LIFE SCIENCES 82.23-24(2008):1196-1202.
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