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学科主题: 临床医学
题名:
Hydrogen sulfide protects rat lung from ischemia-reperfusion injury
作者: Fu, Zhifang1; Liu, Xinmin1; Geng, Bin2; Fang, Liping1; Tang, Chaoshu2
关键词: hydrogen sulfide ; lung ischemia-reperfusion injury ; oxidative stress
刊名: LIFE SCIENCES
发表日期: 2008-06-06
DOI: 10.1016/j.lfs.2008.04.005
卷: 82, 期:23-24, 页:1196-1202
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: OXIDATIVE STRESS ; H2S ; ACTIVATION ; CARDIOMYOCYTES ; PRESERVATION ; INFLAMMATION ; INHIBITOR ; SCAVENGER ; MOUSE
英文摘要:

Recent studies have indicated that hydrogen sulfide (H2S) is capable of modulating many physiological processes, which prompted us to investigate the potential of H2S as a lung protective agent. To explore changes in the generation of endogenous H2S and the role of H2S in the pathogenesis of pulmonary ischemia-reperfusion (I/R) injury in rats, we built an isolated rat lung I/R model. Lungs were subjected to 45 min ischemia followed by reperfusion (45 min) and were pretreated with H2S (50 mu mol/l or 100 mu mol/l) or an irreversible inhibitor of cystathionine-gamma-lyase (CSE), propargylglycine (PPG; 2 mmol/l). We examined indices of lung injury: lung histological change, perfusion flow rate, ratio of lung wet weight to dry weight (w/d), and lung compliance. H2S content and CSE protein expression in lung tissues were measured. Malondialdehyde (MDA) content, activities of superoxide dismutase (SOD) and catalase (CAT), and restraint of superoxide anion (O-2(-)) production in lung tissues were measured to reflect oxidative stress. In the current study, we demonstrated that H2S content and CSE activity in lungs after I/R were significantly higher than those in the control group. Preperfusion with H2S attenuated the lung I/R injury while preperfusion with PPG aggravated the lung I/R injury. H2S preperfusion reduced I/R-induced MDA production and potentiated SOD and CAT activities and the restraint of O-2(-) production in the lungs under I/R, which attenuated lung oxidative injury. These findings suggest that endogenous CSE/H2S pathway might be involved in the pathogenesis of lung I/R injury and that administration of H2S might be of clinical benefit in lung I/R injury. (c) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000256749000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49910
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Dept Geriatr, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Cardiovasc Dis, Beijing 100034, Peoples R China

Recommended Citation:
Fu, Zhifang,Liu, Xinmin,Geng, Bin,et al. Hydrogen sulfide protects rat lung from ischemia-reperfusion injury[J]. LIFE SCIENCES,2008,82(23-24):1196-1202.
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