IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis
Liu, Yixuan1; Dong, Weiwei2; Mou, Quan3; Leng, Yuxin4; Zhang, Lu1; Duan, Liping1
关键词P73 Polymorphism Gastric Cancer
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2014
7期:10页:6820-6825
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]G4C14-TO-A4T14 POLYMORPHISM ; GASTRIC-CANCER ; LUNG-CANCER ; P53 ; RISK ; METAANALYSIS ; ASSOCIATION ; POPULATION ; EXON-2 ; EXPRESSION
英文摘要

Previous studies examining the association between p73 G4A and gastric cancer risk have produced inconsistent results. The objective of this study was to clarify whether p73 G4A plays a major role in the development of gastric cancer. Studies that had examined the association between p73 G4A and gastric cancer risk were identified through PubMed, Science Direct, and CNKI. We selected eligible studies based on inclusion criteria. Odds ratios were estimated using distinct genetic models, and the heterogeneity between studies was explored using Cochran′s Q statistic along with the I-2 statistic. Overall, we found no evidence of a significant association between p73 G4A and risk of gastric cancer. A same trend was also indicated in subgroup analysis by ethnicity. The heterogeneity tests revealed that there was no significant heterogeneity across studies. Our meta-analysis indicates that p73 G4A might not have a major effect on risk of gastric cancer. A much larger study is required to validate our findings.

语种英语
WOS记录号WOS:000345135900045
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49917
专题北京大学第三临床医学院_消化科
北京大学医学部管理机构_科学研究处
北京大学第三临床医学院_危重医学科
作者单位1.Peking Univ, Hlth Sci Ctr, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Gen Hosp PLA, Dept Oncol, Beijing 100853, Peoples R China
3.PLA 252 Hosp, Dept Surg, Baoding 071000, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Hosp 3, Dept Intens Care Unit, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yixuan,Dong, Weiwei,Mou, Quan,et al. Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(10):6820-6825.
APA Liu, Yixuan,Dong, Weiwei,Mou, Quan,Leng, Yuxin,Zhang, Lu,&Duan, Liping.(2014).Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7(10),6820-6825.
MLA Liu, Yixuan,et al."Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7.10(2014):6820-6825.
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