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学科主题: 临床医学
题名:
Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis
作者: Liu, Yixuan1; Dong, Weiwei2; Mou, Quan3; Leng, Yuxin4; Zhang, Lu1; Duan, Liping1
关键词: p73 ; polymorphism ; gastric cancer
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2014
卷: 7, 期:10, 页:6820-6825
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: G4C14-TO-A4T14 POLYMORPHISM ; GASTRIC-CANCER ; LUNG-CANCER ; P53 ; RISK ; METAANALYSIS ; ASSOCIATION ; POPULATION ; EXON-2 ; EXPRESSION
英文摘要:

Previous studies examining the association between p73 G4A and gastric cancer risk have produced inconsistent results. The objective of this study was to clarify whether p73 G4A plays a major role in the development of gastric cancer. Studies that had examined the association between p73 G4A and gastric cancer risk were identified through PubMed, Science Direct, and CNKI. We selected eligible studies based on inclusion criteria. Odds ratios were estimated using distinct genetic models, and the heterogeneity between studies was explored using Cochran′s Q statistic along with the I-2 statistic. Overall, we found no evidence of a significant association between p73 G4A and risk of gastric cancer. A same trend was also indicated in subgroup analysis by ethnicity. The heterogeneity tests revealed that there was no significant heterogeneity across studies. Our meta-analysis indicates that p73 G4A might not have a major effect on risk of gastric cancer. A much larger study is required to validate our findings.

语种: 英语
WOS记录号: WOS:000345135900045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49917
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Gen Hosp PLA, Dept Oncol, Beijing 100853, Peoples R China
3.PLA 252 Hosp, Dept Surg, Baoding 071000, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Hosp 3, Dept Intens Care Unit, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yixuan,Dong, Weiwei,Mou, Quan,et al. Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(10):6820-6825.
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