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学科主题临床医学
The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease
Qu, Zhen1,2,3,4; Cui, Zhao1,2,3,4; Liu, Gang1,2,3,4; Zhao, Ming-hui1,2,3,4,5
刊名BMC IMMUNOLOGY
2013-04-15
DOI10.1186/1471-2172-14-19
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]IMMUNOGLOBULIN-G SUBCLASSES ; ANTI-GBM NEPHRITIS ; NATURAL AUTOANTIBODIES ; GLOMERULONEPHRITIS ; SEVERITY ; RATHER ; FCGR3B
英文摘要

Background: Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subclasses on renal tissue is still unclear. In the current study, we investigated the deposition of the four IgG subclasses using immunohistochemistry in the renal biopsy specimens from 46 patients with anti-GBM disease.

Results: All four IgG subclasses can be detected within the GBM. Anti-GBM IgG3 was detected in all patients (100%), with 39 (84.8%) patients presenting with weak segmental staining and 7 (15.2%) patients with strong linear deposition. Anti-GBM IgG2 was detected in 22 (47.8%) patients, with 20 (90.9%) patients having weak segmental deposition and 2 (9.1%) patients presenting strong linear staining. Anti-GBM IgG1 and IgG4 were detected in 9 (19.6%) and 7 (15.2%) patients, respectively. IgG deposition along tubular basement membrane (TBM) was also detected in 31 (67.4%) patients. Among them, the IgG subclass distribution was similar to that of the deposition within the GBM: IgG1 6.5% (2/31), IgG2 45.2% (14/31), IgG3 100% (31/31) and IgG4 9.7% (3/31). We observed increased inflammatory cell infiltration into the interstitium in patients with increased anti-TBM IgG3 deposits (P=0.031).

Conclusions: Anti-GBM IgG3 predominantly deposits along GBM and TBM on renal biopsy specimens from patients with anti-GBM disease, which may be involved in the development of renal injury of the disease.

语种英语
WOS记录号WOS:000318658100001
项目编号2012CB517702 ; 81021004 ; 81170645
资助机构Chinese 973 project ; Natural Science Fund of China ; National Natural Science Fund of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49932
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Renal Div, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
5.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
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GB/T 7714
Qu, Zhen,Cui, Zhao,Liu, Gang,et al. The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease[J]. BMC IMMUNOLOGY,2013,14.
APA Qu, Zhen,Cui, Zhao,Liu, Gang,&Zhao, Ming-hui.(2013).The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease.BMC IMMUNOLOGY,14.
MLA Qu, Zhen,et al."The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease".BMC IMMUNOLOGY 14(2013).
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