北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease
作者: Qu, Zhen1,2,3,4; Cui, Zhao1,2,3,4; Liu, Gang1,2,3,4; Zhao, Ming-hui1,2,3,4,5
刊名: BMC IMMUNOLOGY
发表日期: 2013-04-15
DOI: 10.1186/1471-2172-14-19
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: IMMUNOGLOBULIN-G SUBCLASSES ; ANTI-GBM NEPHRITIS ; NATURAL AUTOANTIBODIES ; GLOMERULONEPHRITIS ; SEVERITY ; RATHER ; FCGR3B
英文摘要:

Background: Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subclasses on renal tissue is still unclear. In the current study, we investigated the deposition of the four IgG subclasses using immunohistochemistry in the renal biopsy specimens from 46 patients with anti-GBM disease.

Results: All four IgG subclasses can be detected within the GBM. Anti-GBM IgG3 was detected in all patients (100%), with 39 (84.8%) patients presenting with weak segmental staining and 7 (15.2%) patients with strong linear deposition. Anti-GBM IgG2 was detected in 22 (47.8%) patients, with 20 (90.9%) patients having weak segmental deposition and 2 (9.1%) patients presenting strong linear staining. Anti-GBM IgG1 and IgG4 were detected in 9 (19.6%) and 7 (15.2%) patients, respectively. IgG deposition along tubular basement membrane (TBM) was also detected in 31 (67.4%) patients. Among them, the IgG subclass distribution was similar to that of the deposition within the GBM: IgG1 6.5% (2/31), IgG2 45.2% (14/31), IgG3 100% (31/31) and IgG4 9.7% (3/31). We observed increased inflammatory cell infiltration into the interstitium in patients with increased anti-TBM IgG3 deposits (P=0.031).

Conclusions: Anti-GBM IgG3 predominantly deposits along GBM and TBM on renal biopsy specimens from patients with anti-GBM disease, which may be involved in the development of renal injury of the disease.

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81170645
项目资助者: Chinese 973 project ; Natural Science Fund of China ; National Natural Science Fund of China
WOS记录号: WOS:000318658100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49932
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Med, Renal Div, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
5.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Qu, Zhen,Cui, Zhao,Liu, Gang,et al. The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease[J]. BMC IMMUNOLOGY,2013,14.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qu, Zhen]'s Articles
[Cui, Zhao]'s Articles
[Liu, Gang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qu, Zhen]‘s Articles
[Cui, Zhao]‘s Articles
[Liu, Gang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace