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学科主题: 临床医学
题名:
Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS
作者: Li, Hui1,2,3; Chen, Yuan1,2; Yan, Li-ying1,2; Qiao, Jie1,2
关键词: Polycystic ovary syndrome ; CYP17 ; P450scc ; Rat
刊名: ENDOCRINE
发表日期: 2013-02-01
DOI: 10.1007/s12020-012-9739-3
卷: 43, 期:1, 页:184-190
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: POLYCYSTIC-OVARY-SYNDROME ; HUMAN CHORIONIC-GONADOTROPIN ; GROWTH-FACTOR-I ; ANDROGEN BIOSYNTHESIS ; THECA CELLS ; INSULIN ; CYSTS ; HYPERINSULINEMIA ; CHOLESTEROL ; PREVALENCE
英文摘要:

The objective of the present study was to characterize the effect of insulin plus hCG on the expression of steroidogenic enzymes (P450scc and CYP17) in polycystic ovaries of rats. Changes in estrous cycle, ovarian morphology, hormonal levels, and protein levels by immunohistochemistry and western-blot were determined. Rats treated with insulin plus hCG displayed abnormal estrous cycles with increasing androgen biosynthesis. Meanwhile, insulin plus hCG resulted in multiple large cysts with diminished granulosa layers and increased thecal layers and stromal-interstitial tissue. Moreover, there was an increase in the expression of P450scc and CYP17 in thecal and stromal cells in our PCOS rat model compared with control rats. These results indicate that administration of insulin with hCG can synergistically result in endogenous hyperandrogenism which may partially upregulate the expression of steroidogenic enzymes in ovarian tissue.

语种: 英语
所属项目编号: 81000234 ; 20090001110090
项目资助者: National Natural Sciences Foundation of China ; Doctoral Fund of Ministry of Education of China
WOS记录号: WOS:000313069600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49933
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
3.Dezhou Univ, Dept Med, Dezhou, Shandong, Peoples R China

Recommended Citation:
Li, Hui,Chen, Yuan,Yan, Li-ying,et al. Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS[J]. ENDOCRINE,2013,43(1):184-190.
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