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Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS
Li, Hui1,2,3; Chen, Yuan1,2; Yan, Li-ying1,2; Qiao, Jie1,2
关键词Polycystic Ovary Syndrome Cyp17 P450scc Rat
刊名ENDOCRINE
2013-02-01
DOI10.1007/s12020-012-9739-3
43期:1页:184-190
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]POLYCYSTIC-OVARY-SYNDROME ; HUMAN CHORIONIC-GONADOTROPIN ; GROWTH-FACTOR-I ; ANDROGEN BIOSYNTHESIS ; THECA CELLS ; INSULIN ; CYSTS ; HYPERINSULINEMIA ; CHOLESTEROL ; PREVALENCE
英文摘要

The objective of the present study was to characterize the effect of insulin plus hCG on the expression of steroidogenic enzymes (P450scc and CYP17) in polycystic ovaries of rats. Changes in estrous cycle, ovarian morphology, hormonal levels, and protein levels by immunohistochemistry and western-blot were determined. Rats treated with insulin plus hCG displayed abnormal estrous cycles with increasing androgen biosynthesis. Meanwhile, insulin plus hCG resulted in multiple large cysts with diminished granulosa layers and increased thecal layers and stromal-interstitial tissue. Moreover, there was an increase in the expression of P450scc and CYP17 in thecal and stromal cells in our PCOS rat model compared with control rats. These results indicate that administration of insulin with hCG can synergistically result in endogenous hyperandrogenism which may partially upregulate the expression of steroidogenic enzymes in ovarian tissue.

语种英语
WOS记录号WOS:000313069600027
项目编号81000234 ; 20090001110090
资助机构National Natural Sciences Foundation of China ; Doctoral Fund of Ministry of Education of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49933
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
3.Dezhou Univ, Dept Med, Dezhou, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Li, Hui,Chen, Yuan,Yan, Li-ying,et al. Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS[J]. ENDOCRINE,2013,43(1):184-190.
APA Li, Hui,Chen, Yuan,Yan, Li-ying,&Qiao, Jie.(2013).Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS.ENDOCRINE,43(1),184-190.
MLA Li, Hui,et al."Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS".ENDOCRINE 43.1(2013):184-190.
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