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学科主题: 临床医学
题名:
Weaning critically ill patients from mechanical ventilation: A prospective cohort study
作者: Pu, Lin1,2; Zhu, Bo1; Jiang, Li1; Du, Bin3; Zhu, Xi4; Li, Ang5; Li, Gang6; He, Zhongjie7; Chen, Wei8; Ma, Penglin9; Jia, Jianguo10; Xu, Yuan11; Zhou, Jianxin12; Qin, Long13; Zhan, Qingyuan14; Li, Wenxiong15; Jiang, Qi1; Wang, Meiping1; Lou, Ran1; Xi, XiuMing1
关键词: Epidemiology ; Intensive care unit ; Ventilation ; Weaning
刊名: JOURNAL OF CRITICAL CARE
发表日期: 2015-08-01
DOI: 10.1016/j.jcrc.2015.04.001
卷: 30, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; PRESSURE SUPPORT VENTILATION ; AUTOMATIC TUBE COMPENSATION ; RANDOMIZED CONTROLLED-TRIAL ; INTENSIVE-CARE-UNIT ; NONINVASIVE VENTILATION ; BREATHING TRIAL ; RISK-FACTORS ; EXTUBATION ; FAILURE
英文摘要:

Purpose: A proposal was made at the International Consensus Conference to classify weaning of patients in intensive care units from mechanical ventilation into simple, difficult, and prolonged weaning groups based on the difficulty and length of the weaning process. The objective of the present study was to determine the incidence and outcome of weaning according to these new categories.

Methods: We examined the weaning of patients in intensive care units from mechanical ventilation in a prospective multicenter cohort study.

Results: In total, 343 patients were included in the final analysis. Simple, difficult, and prolonged weaning occurred in 200 (58%), 99 (29%), and 44 (13%) patients, respectively. Hospital mortality rates were higher for patients in the prolonged weaning group than in the simple and difficult weaning groups. Multivariate analysis revealed that a lower Glasgow Coma Scale score (P < .014) and hypercapnia at the beginning of the first spontaneous breathing trial (P = .038) were independent predictors of prolonged weaning.

Conclusions: Patients who experienced prolonged weaning had significantly higher mortality rates than patients who experienced either simple or difficult weaning. A lower Glasgow Coma Scale score and hypercapnia at the beginning of the weaning process were independent risk factors for prolonged weaning. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: H020920020530
项目资助者: Research Fund of Capital Medical Development
WOS记录号: WOS:000356066100041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49953
Appears in Collections:北京大学第三临床医学院_危重医学科_期刊论文

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作者单位: 1.ICU Beijing Haidian Hosp, Dept Crit Care Med, Beijing 100080, Peoples R China
2.Capital Med Univ, ICU Fu Xing Hosp, Dept Crit Care Med, Beijing 10038, Peoples R China
3.Capital Med Univ, ICU Beijing Ditan Hosp, Dept Crit Care Med, Beijing 100015, Peoples R China
4.MICU Peking Union Med Coll Hosp, Med Intens Care Unit, Beijing 100730, Peoples R China
5.ICU Peking Univ, Hosp 3, Dept Crit Care Med, Beijing 100191, Peoples R China
6.Capital Med Univ, ICU Beijing Friendship Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
7.ICU China Japan Friendship Hosp, Dept Crit Care Med, Beijing 100029, Peoples R China
8.Gen Hosp Peoples Liberat Army, ICU Affiliated Hosp 1, Dept Crit Care Med, Beijing 100048, Peoples R China
9.Capital Med Univ, ICU Beijing Shijitan Hosp, Dept Crit Care Med, Beijing 100038, Peoples R China
10.ICU 309th Hosp Chinese Peoples Liberat Army, Dept Crit Care Med, Beijing 100094, Peoples R China
11.Capital Med Univ, SICU Xuan Wu Hosp, Surg Intens Care Unit, Beijing 100053, Peoples R China
12.Capital Med Univ, ICU Beijing Tong Ren Hosp, Dept Crit Care Med, Beijing 100730, Peoples R China
13.Capital Med Univ, ICU Beijing Tian Tan Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
14.China Japan Friendship Hosp, Dept Resp, Beijing 100029, Peoples R China
15.Capital Med Univ, SICU Beijing Chao Yang Hosp, Surg Intens Care Unit, Beijing 100020, Peoples R China

Recommended Citation:
Pu, Lin,Zhu, Bo,Jiang, Li,et al. Weaning critically ill patients from mechanical ventilation: A prospective cohort study[J]. JOURNAL OF CRITICAL CARE,2015,30(4).
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