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学科主题临床医学
Weaning critically ill patients from mechanical ventilation: A prospective cohort study
Pu, Lin1,2; Zhu, Bo1; Jiang, Li1; Du, Bin3; Zhu, Xi4; Li, Ang5; Li, Gang6; He, Zhongjie7; Chen, Wei8; Ma, Penglin9; Jia, Jianguo10; Xu, Yuan11; Zhou, Jianxin12; Qin, Long13; Zhan, Qingyuan14; Li, Wenxiong15; Jiang, Qi1; Wang, Meiping1; Lou, Ran1; Xi, XiuMing1
关键词Epidemiology Intensive Care Unit Ventilation Weaning
刊名JOURNAL OF CRITICAL CARE
2015-08-01
DOI10.1016/j.jcrc.2015.04.001
30期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine
研究领域[WOS]General & Internal Medicine
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; PRESSURE SUPPORT VENTILATION ; AUTOMATIC TUBE COMPENSATION ; RANDOMIZED CONTROLLED-TRIAL ; INTENSIVE-CARE-UNIT ; NONINVASIVE VENTILATION ; BREATHING TRIAL ; RISK-FACTORS ; EXTUBATION ; FAILURE
英文摘要

Purpose: A proposal was made at the International Consensus Conference to classify weaning of patients in intensive care units from mechanical ventilation into simple, difficult, and prolonged weaning groups based on the difficulty and length of the weaning process. The objective of the present study was to determine the incidence and outcome of weaning according to these new categories.

Methods: We examined the weaning of patients in intensive care units from mechanical ventilation in a prospective multicenter cohort study.

Results: In total, 343 patients were included in the final analysis. Simple, difficult, and prolonged weaning occurred in 200 (58%), 99 (29%), and 44 (13%) patients, respectively. Hospital mortality rates were higher for patients in the prolonged weaning group than in the simple and difficult weaning groups. Multivariate analysis revealed that a lower Glasgow Coma Scale score (P < .014) and hypercapnia at the beginning of the first spontaneous breathing trial (P = .038) were independent predictors of prolonged weaning.

Conclusions: Patients who experienced prolonged weaning had significantly higher mortality rates than patients who experienced either simple or difficult weaning. A lower Glasgow Coma Scale score and hypercapnia at the beginning of the weaning process were independent risk factors for prolonged weaning. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000356066100041
项目编号H020920020530
资助机构Research Fund of Capital Medical Development
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49953
专题北京大学第三临床医学院_危重医学科
北京大学第三临床医学院_检验科
作者单位1.ICU Beijing Haidian Hosp, Dept Crit Care Med, Beijing 100080, Peoples R China
2.Capital Med Univ, ICU Fu Xing Hosp, Dept Crit Care Med, Beijing 10038, Peoples R China
3.Capital Med Univ, ICU Beijing Ditan Hosp, Dept Crit Care Med, Beijing 100015, Peoples R China
4.MICU Peking Union Med Coll Hosp, Med Intens Care Unit, Beijing 100730, Peoples R China
5.ICU Peking Univ, Hosp 3, Dept Crit Care Med, Beijing 100191, Peoples R China
6.Capital Med Univ, ICU Beijing Friendship Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
7.ICU China Japan Friendship Hosp, Dept Crit Care Med, Beijing 100029, Peoples R China
8.Gen Hosp Peoples Liberat Army, ICU Affiliated Hosp 1, Dept Crit Care Med, Beijing 100048, Peoples R China
9.Capital Med Univ, ICU Beijing Shijitan Hosp, Dept Crit Care Med, Beijing 100038, Peoples R China
10.ICU 309th Hosp Chinese Peoples Liberat Army, Dept Crit Care Med, Beijing 100094, Peoples R China
11.Capital Med Univ, SICU Xuan Wu Hosp, Surg Intens Care Unit, Beijing 100053, Peoples R China
12.Capital Med Univ, ICU Beijing Tong Ren Hosp, Dept Crit Care Med, Beijing 100730, Peoples R China
13.Capital Med Univ, ICU Beijing Tian Tan Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
14.China Japan Friendship Hosp, Dept Resp, Beijing 100029, Peoples R China
15.Capital Med Univ, SICU Beijing Chao Yang Hosp, Surg Intens Care Unit, Beijing 100020, Peoples R China
推荐引用方式
GB/T 7714
Pu, Lin,Zhu, Bo,Jiang, Li,et al. Weaning critically ill patients from mechanical ventilation: A prospective cohort study[J]. JOURNAL OF CRITICAL CARE,2015,30(4).
APA Pu, Lin.,Zhu, Bo.,Jiang, Li.,Du, Bin.,Zhu, Xi.,...&Xi, XiuMing.(2015).Weaning critically ill patients from mechanical ventilation: A prospective cohort study.JOURNAL OF CRITICAL CARE,30(4).
MLA Pu, Lin,et al."Weaning critically ill patients from mechanical ventilation: A prospective cohort study".JOURNAL OF CRITICAL CARE 30.4(2015).
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