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Evolution of thymus organogenesis
Ge, Qing1; Zhao, Yong2
关键词Thymus Evolution Vertebrate Thymic Epithelial Cells Organogenesis
刊名DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
2013
DOI10.1016/j.dci.2012.01.002
39期:1-2页:85-90
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology ; Zoology
资助者Natural Basic Research Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education ; Natural Basic Research Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Immunology ; Zoology
关键词[WOS]ADAPTIVE IMMUNE-SYSTEM ; LYMPHOCYTE-LIKE CELLS ; STARFISH AXIAL ORGAN ; NEURAL CREST ; PHARYNGEAL POUCH ; EPITHELIAL-CELLS ; IN-VIVO ; ANCESTRAL VERTEBRATE ; ANTIGEN PRESENTATION ; CENTRAL TOLERANCE
英文摘要

The thymus is the primary organ for functional T lymphocyte development in jawed vertebrates. A new study in the jawless fish, lampreys, indicates the existence of a primitive thymus in these surviving representatives of the most ancient vertebrates, providing strong evidence of co-evolution of T cells and thymus. This review summarizes the wealth of data that have been generated towards understanding the evolution of the thymus in the vertebrates. Progress in identifying genetic networks and cellular mechanisms that control thymus organogenesis in mammals and their evolution in lower species may inspire the development of new strategies for medical interventions targeting faulty thymus functions. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号2010CB945300 ; 2011CB711000 ; 31070787 ; C8113005 ; NCET-10-0175/BMU20100005 ; 20100001110049
资助者Natural Basic Research Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education ; Natural Basic Research Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000312617900009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49958
专题基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Key Lab Med Immunol, Minist Hlth,Dept Immunol,Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Ge, Qing,Zhao, Yong. Evolution of thymus organogenesis[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2013,39(1-2):85-90.
APA Ge, Qing,&Zhao, Yong.(2013).Evolution of thymus organogenesis.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,39(1-2),85-90.
MLA Ge, Qing,et al."Evolution of thymus organogenesis".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 39.1-2(2013):85-90.
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