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学科主题: 临床医学
题名:
Population Pharmacokinetics of Naringin in Total Flavonoids of Drynaria Fortunei (Kunze) J. Sm. in Chinese Women with Primary Osteoporosis
作者: Wang Jian-nong2; Jiang Jun-jie1; Xie Yan-ming1; Wei Xu1; Li Jian-peng1; Duan Jing-li3; Xiong Xin3
关键词: naringin ; population pharmacokinetics ; Qianggu Capsule ; total flavonoids of Drynaria fortunei
刊名: CHINESE JOURNAL OF INTEGRATIVE MEDICINE
发表日期: 2012-12-01
DOI: 10.1007/s11655-012-1296-0
卷: 18, 期:12, 页:925-933
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; PLASMA ; RATS
英文摘要:

Objective: To evaluate the effect of covariates on the pharmacokinetic profiles of naringin in the total flavonoids of Drynaria fortunei (Kunze) J. Sm. in the Qianggu Capsule by evaluating Chinese women with primary osteoporosis. Methods: A total of 98 female patients from the communities of Jingshan, Beixinqiao, Jiaodaokou, Chaoyangmen, and Donghuamen in Beijing, China, aged 40 to 80 years, were included in this study. Blood samples were collected before and 0.5, 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after a single oral dose of Qianggu Capsule. The concentration in blood samples from 32 patients before and 0.5, 1, 2, 3, and 4 h after drug administration were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, and full set of pharmacokinetic data was analyzed with nonlinear mixed-effect modeling (NONMEM) software. The mean of population parameters clearance (Cl), central distribution volume (V), absorption rate constant (Ka1), inter-compartmental clearance (C2), peripheral distribution volume (V2) were set as parameters and estimated through base model, covariate model, and final model. Age, height, weight, blood urea nitrogen (BUN), serum creatinine (Scr), alanine transaminase (ALT), aspartate transaminase (AST), hyperlipidemia, Liver (Gan) Kidney (Shen) yin insufficiency (GSYI), Kidney (Shen) yang insufficiency (SYI) were set as covariates. Results: The relationships between these parameters and covariates were analyzed. The results showed that Cl was the main parameter influenced by the selected covariates among the population parameters, and the relationships between the covariates and Cl were analyzed, among the selected covariates hyperlipidemia was identified as significant covariate of Cl. Conclusion: The pharmacokinetic behaviors of naringin are altered with hyperlipidemia in Chinese women with primary osteoporosis.

语种: 英语
所属项目编号: 2009ZX09502-030
项目资助者: Significant Drug Research and Development in Important State Science and Technology Specific and Key Technique Research
WOS记录号: WOS:000311763600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49959
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.China Acad Chinese Med Sci, Chinese Clin Basic Inst, Beijing 100700, Peoples R China
2.China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100093, Peoples R China
3.Peking Univ, Dept Pharmaceut, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Wang Jian-nong,Jiang Jun-jie,Xie Yan-ming,et al. Population Pharmacokinetics of Naringin in Total Flavonoids of Drynaria Fortunei (Kunze) J. Sm. in Chinese Women with Primary Osteoporosis[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2012,18(12):925-933.
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