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学科主题: 药学
题名:
Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization
作者: Yang, Ke Wei; Li, Xin Ru; Yang, Zhuo Li; Li, Ping Zhu; Wang, Fei; Liu, Yan
关键词: polyion complex micelles ; chitosan ; diammonium glycyrrhizinate ; in vitro release ; liver-targeted micelles
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2009
DOI: 10.1002/jbm.a.31866
卷: 88A, 期:1, 页:140-148
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: BLOCK-COPOLYMER MICELLES ; POLY(ETHYLENE GLYCOL) ; DRUG-DELIVERY ; CHITOSAN ; NANOPARTICLES ; RELEASE ; TUMOR ; GENE ; DERIVATIVES ; HYDROLYSIS
英文摘要:

Polyion complex micelles (PIC micelles) based on methoxy poly(ethylene glycol)-grafted-chitosan (mPEG-g-Chitosan) and lactose-conjugated PEG-grafted-chitosan (Lac-PEG-g-Chitosan) were designed as carriers for mionic drugs. Diammonium glycyrrhizinate (DG)-loaded conventional PIC micelles (mPIC micelles) and lactose-modified PIC micelles (Lac-PIC micelles) were prepared successfully with encapsulation efficiency of 97.4%, and 967%, respectively. These micelles were uniform spherical particles with a mean size of 21.6 and 26.4 nm by transmission electron microscopy, respectively. No significant size change of these micelles in three months indicated their good physical stability. The in vitro drug release behavior of mPIC micelles in cliff rent media as well as the changes of size and zeta potential demonstrated that the drug was released mainly through swelling and diffusion induced by ion exchange. The pharmacokinetic experiments showed that the area under the Curve of DG plasma concentration-time profile in rats for mPIC micelles and Lac-PIC micelles were 1.2 times and 0.4 times higher than that for DG injection, respectively. The liver targeting ability of both mPIC micelles and Lac-PIC micelles was evaluated in rats, revealing that Lac-PIC micelles could deliver more DG to liver than mPIC micelles. Therefore, the Lac-PIC micelles prepared in this study were promising liver-targeted nanocarriers for DG. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 140-148, 2009

语种: 英语
WOS记录号: WOS:000261471900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49960
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Ke Wei,Li, Xin Ru,Yang, Zhuo Li,et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2009,88A(1):140-148.
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