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Acetyl-L-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells
Zhang, Zhaofeng; Zhao, Ming; Li, Qiong; Zhao, Haifeng; Wang, Junbo; Li, Yong
关键词Acetyl-l-carnitine Amp-activated Protein Kinase Insulin Resistance Tumor Necrosis Factor-alpha
刊名FEBS LETTERS
2009-01-22
DOI10.1016/j.febslet.2008.12.053
583期:2页:470-474
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]TYPE-2 DIABETIC-PATIENTS ; TUMOR-NECROSIS-FACTOR ; GLUCOSE DISPOSAL ; NEUROPATHY ; ADIPOCYTES
英文摘要

In this study, we demonstrated effects of acetyl-L-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in rat L6 cells. TNF-alpha downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-alpha-induced insulin resistance through AMPK pathway in skeletal muscle cells. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000263101000035
项目编号2006BAD27B01
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49966
专题北京大学公共卫生学院
北京大学药学院_化学生物学系
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Zhaofeng,Zhao, Ming,Li, Qiong,et al. Acetyl-L-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells[J]. FEBS LETTERS,2009,583(2):470-474.
APA Zhang, Zhaofeng,Zhao, Ming,Li, Qiong,Zhao, Haifeng,Wang, Junbo,&Li, Yong.(2009).Acetyl-L-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells.FEBS LETTERS,583(2),470-474.
MLA Zhang, Zhaofeng,et al."Acetyl-L-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells".FEBS LETTERS 583.2(2009):470-474.
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