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学科主题: 基础医学
题名:
Hepatocellular Carcinoma Cells Deteriorate the Biophysical Properties of Dendritic Cells
作者: Zeng, Zhu1,2,3,4; Yao, Weijuan1,3,4; Xu, Xiaofeng1; Xu, Guoqiang2; Long, Jinhua2; Wang, Xianwei1; Wen, Zongyao1; Chien, Shu3,4
关键词: Dendritic cells ; Biophysics ; Hepatocellular carcinoma ; Microenvironment
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2009-09-01
DOI: 10.1007/s12013-009-9055-6
卷: 55, 期:1, 页:33-43
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: PERIPHERAL-BLOOD ; CANCER ; MECHANISMS ; INFECTION ; MIGRATION
英文摘要:

Dendritic cells (DCs) are potent antigen-presenting cells and induce antigen-specific immune responses in the organism. The dysfunction of DCs has been implicated in tumor-bearing host. In order to elucidate the effects of tumor microenvironment on the functions of DCs from interdisciplinary aspects, we characterized the biophysical properties of DCs co-cultured with hepatocellular carcinoma cells (HCC). The results showed that the biophysical characteristics of immature and mature DCs were severely impaired by HCC compared with those under normal conditions, including the increased osmotic fragilities, decreased cell membrane fluidities, increased membrane viscoelastic properties, dysfunction and increased expression of cytoskeleton protein F-actin, as well as the deteriorated transendothelium migration. The impaired biophysical properties of DCs may be one of many aspects of the immune escape mechanisms of tumors. These results are clinically and instructionally significant with regard to how to enhance efficiency of the anti-tumor therapy based on DCs.

语种: 英语
所属项目编号: 10572007 ; 30770532 ; 2009038
项目资助者: National Natural Science Foundations of China ; Scientific and Technological Funding ; The Governor Funding of Guizhou Province, China
WOS记录号: WOS:000268003000003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49976
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
2.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R China
3.Guiyang Med Coll, Guiyang, Guizhou Prov, Peoples R China
4.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Recommended Citation:
Zeng, Zhu,Yao, Weijuan,Xu, Xiaofeng,et al. Hepatocellular Carcinoma Cells Deteriorate the Biophysical Properties of Dendritic Cells[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2009,55(1):33-43.
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