IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Hepatocellular Carcinoma Cells Deteriorate the Biophysical Properties of Dendritic Cells
Zeng, Zhu1,2,3,4; Yao, Weijuan1,3,4; Xu, Xiaofeng1; Xu, Guoqiang2; Long, Jinhua2; Wang, Xianwei1; Wen, Zongyao1; Chien, Shu3,4
关键词Dendritic cells Biophysics Hepatocellular carcinoma Microenvironment
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2009-09-01
DOI10.1007/s12013-009-9055-6
55期:1页:33-43
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]PERIPHERAL-BLOOD ; CANCER ; MECHANISMS ; INFECTION ; MIGRATION
英文摘要

Dendritic cells (DCs) are potent antigen-presenting cells and induce antigen-specific immune responses in the organism. The dysfunction of DCs has been implicated in tumor-bearing host. In order to elucidate the effects of tumor microenvironment on the functions of DCs from interdisciplinary aspects, we characterized the biophysical properties of DCs co-cultured with hepatocellular carcinoma cells (HCC). The results showed that the biophysical characteristics of immature and mature DCs were severely impaired by HCC compared with those under normal conditions, including the increased osmotic fragilities, decreased cell membrane fluidities, increased membrane viscoelastic properties, dysfunction and increased expression of cytoskeleton protein F-actin, as well as the deteriorated transendothelium migration. The impaired biophysical properties of DCs may be one of many aspects of the immune escape mechanisms of tumors. These results are clinically and instructionally significant with regard to how to enhance efficiency of the anti-tumor therapy based on DCs.

语种英语
WOS记录号WOS:000268003000003
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49976
专题北京大学基础医学院_生物物理学系
作者单位1.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
2.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R China
3.Guiyang Med Coll, Guiyang, Guizhou Prov, Peoples R China
4.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
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GB/T 7714
Zeng, Zhu,Yao, Weijuan,Xu, Xiaofeng,et al. Hepatocellular Carcinoma Cells Deteriorate the Biophysical Properties of Dendritic Cells[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2009,55(1):33-43.
APA Zeng, Zhu.,Yao, Weijuan.,Xu, Xiaofeng.,Xu, Guoqiang.,Long, Jinhua.,...&Chien, Shu.(2009).Hepatocellular Carcinoma Cells Deteriorate the Biophysical Properties of Dendritic Cells.CELL BIOCHEMISTRY AND BIOPHYSICS,55(1),33-43.
MLA Zeng, Zhu,et al."Hepatocellular Carcinoma Cells Deteriorate the Biophysical Properties of Dendritic Cells".CELL BIOCHEMISTRY AND BIOPHYSICS 55.1(2009):33-43.
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