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学科主题: 临床医学
题名:
Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort
作者: Mukhopadhyay, Monojitketan16; Yeung, Roseanne O.1; Zhang, Yuying1; Luk, Andrea2; Yang, Wenying3; Sobrepena, Leorino4; Yoon, Kun-Ho5; Aravind, S. R.6; Sheu, Wayne7; Thy Khue Nguyen8; Ozaki, Risa2; Deerochanawong, Chaicharn9; Tsang, Chiu Chi1; Chan, Wing-Bun10; Hong, Eun Gyoung11; Trung Quan Do12; Cheung, Yu13; Brown, Nicola14; Goh, Su Yen15; Ma, Ronald C.1; Ojha, Arvind Kumar17; Chakraborty, Shaibal18; Kong, Alice P.1; Lau, Winnie2; Jia, Weiping19; Li, Wenhui20; Guo, Xiaohui20; Bian, Rongwen21; Weng, Jianping22; Ji, Linong23; Reyes-dela Rosa, Mercedes24; Toledo, Ronaldo M.25; Himathongkam, Thep26; Yoo, Soon-Jib27; Chow, C. C.2; Ho, Larry L. T.28,29; Chuang, Lee-Ming30; Tutino, Greg1; Tong, Peter C.31; So, Wing-Yee2; Wolthers, Troels14; Ko, Gary1; Lyubomirsky, Greg14; Chan, Juliana C. N.1
刊名: LANCET DIABETES & ENDOCRINOLOGY
发表日期: 2014-12-01
DOI: 10.1016/S2213-8587(14)70137-8
卷: 2, 期:12, 页:935-943
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: RISK-FACTORS ; GLYCEMIC CONTROL ; CHINESE PATIENTS ; COMPLICATIONS ; MORTALITY ; CARE ; MANAGEMENT ; MELLITUS ; DISEASE ; YOUTH
英文摘要:

Background The prevalence of diabetes is increasing in young adults in Asia, but little is known about metabolic control or the burden of associated complications in this population. We assessed the prevalence of young-onset versus late-onset type 2 diabetes, and associated risk factors and complication burdens, in the Joint Asia Diabetes Evaluation (JADE) cohort.

Methods JADE is an ongoing prospective cohort study. We enrolled adults with type 2 diabetes from 245 outpatient clinics in nine Asian countries or regions. We classified patients as having young-onset diabetes if they were diagnosed before the age of 40 years, and as having late-onset diabetes if they were diagnosed at 40 years or older. Data for participants′ first JADE assessment was extracted for cross-sectional analysis. We compared clinical characteristics, metabolic risk factors, and the prevalence of complications between participants with young-onset diabetes and late-onset diabetes.

Findings Between Nov 1, 2007, and Dec 21, 2012, we enrolled 41 029 patients (15 341 from Hong Kong, 9107 from India, 7712 from Philippines, 5646 from China, 1751 from South Korea, 705 from Vietnam, 385 from Singapore, 275 from Thailand, 107 from Taiwan). 7481 patients (18%) had young-onset diabetes, with age at diagnosis of mean 32.9 years [SD 5.7] versus 53.9 years [9.0] with late-onset diabetes (n=33 548). Those with young-onset diabetes had longer disease duration (median 10 years [IQR 3-18]) than those with late-onset diabetes (5 years [2-11]). Fewer patients with young-onset diabetes achieved HbA(1c) concentrations lower than 7% compared to those with late-onset diabetes (27% vs 42%; p<0.0001) Patients with young-onset diabetes had higher mean concentrations of HbA(1c) (mean 8.32% [SD 2.03] vs 7.69% [1.82]; p<0.0001), LDL cholesterol (2.78 mmol/L [0.96] vs 2.74 [0.93]; p=0.009), and a higher prevalence of retinopathy (1363 [20%] vs 5714 (18%); p=0.011) than those with late-onset diabetes, but were less likely to receive statins (2347 [31%] vs 12 441 [37%]; p< 0.0001) and renin-angiotensin-system inhibitors (1868 [25%] vs 9665 [29%]; p=0.006).

Interpretation In clinic-based settings across Asia, one in five adult patients had young-onset diabetes. Compared with patients with late-onset diabetes, metabolic control in those with young-onset diabetes was poor, and fewer received organ-protective drugs. Given the risk conferred by long-term suboptimum metabolic control, our findings suggest an impending epidemic of young-onset diabetic complications.

语种: 英语
项目资助者: Merck educational grant ; University of British Columbia Clinical Investigator Program
WOS记录号: WOS:000347780700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49977
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Union Med Coll Hosp, Beijing, Peoples R China
2.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
3.Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
4.China Japan Friendship Hosp, Beijing, Peoples R China
5.Heart Jesus Hosp, San Jose City, Philippines
6.Catholic Univ Korea, Seoul, South Korea
7.Diacon Hosp, Bangalore, Karnataka, India
8.Taichung Vet Gen Hosp, Taichung, Taiwan
9.HCMC Univ Pharmaceut & Med, Ho Chi Minh City, Vietnam
10.Rajavithi Hosp, Bangkok, Thailand
11.Qualigen Diabet Ctr, Hong Kong, Hong Kong, Peoples R China
12.Hallym Univ, Coll Med, Seoul, South Korea
13.Bach Mai Hosp, Hanoi, Vietnam
14.Ma On Shan Family Med Ctr, Hong Kong, Hong Kong, Peoples R China
15.Asia Diabet Fdn, Hong Kong, Hong Kong, Peoples R China
16.Singapore Gen Hosp, Singapore, Singapore
17.Dr MK Mukhopadhyays Diabet Clin, Kolkata, India
18.ILS Hosp, Kolkata, India
19.Seth Sukhlal Karnani Mem Hosp, Kolkata, India
20.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200030, Peoples R China
21.Jiangsu Prov Hosp, Nanjing, Jiangsu, Peoples R China
22.Sun Yat Sen Univ, Affi liated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
23.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
24.Tondo Hosp, Manila, Philippines
25.Senor St Nino Hosp, Camiling, Philippines
26.Theptarin Hosp, Bangkok, Thailand
27.Catholic Univ Bucheon, St Marys Hosp, Puchon, South Korea
28.Taipei Vet Gen Hosp, Taipei, Taiwan
29.Natl Yang Ming Univ, Taipei 112, Taiwan
30.Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan
31.Qualigen Diabet Ctr, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Mukhopadhyay, Monojitketan,Yeung, Roseanne O.,Zhang, Yuying,et al. Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort[J]. LANCET DIABETES &amp; ENDOCRINOLOGY,2014,2(12):935-943.
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