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Arachidonic Acid Metabolites Inhibit the Stimulatory Effect of Angiotensin II in Renal Proximal Tubules
Li, Yuchong1,2; Yamada, Hideomi1; Kita, Yoshihiro3; Suzuki, Masashi1; Endo, Yoko1; Horita, Shoko1; Yamazaki, Osamu1; Shimizu, Takao3; Seki, George1; Fujita, Toshiro1
关键词Angiotensin Ii Renal Proximal Tubules Na-hco(3) Cotransporter Extracellular Signal-regulated Kinase Epoxyeicosatrienoic Acid
刊名HYPERTENSION RESEARCH
2008-12-01
31期:12页:2155-2164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CYTOSOLIC PHOSPHOLIPASE A(2) ; ACTIVATED PROTEIN-KINASE ; BIPHASIC REGULATION ; EPOXYEICOSATRIENOIC ACIDS ; BICARBONATE ABSORPTION ; NA+-HCO3-COTRANSPORTER ; EPITHELIAL-CELLS ; MUSCLE-CELLS ; 1A RECEPTOR ; TRANSPORT
英文摘要

Angiotensin II (Ang II) regulates renal proximal transport In a biphasic way via Ang II type I receptor (AT(1)). Whereas extracellular signal-regulated kinase (ERK) activation mediates the stimulatory effect, cytosolic phospholipase A(2) (cPLA(2)) mediates the Inhibitory effect Independently of ERK. In this study, we tested the hypothesis that the cPLA(2)/P450 epoxygenese pathway might work to suppress the Ang II-mediated ERK activation. In the presence of arachidonic acid or 5,6-epoxyeicosatrienoic acid (EET), Ang II failed to stimulate the Na-HCO(3) cotransporter activity In renal proximal tubules isolated from wild-type, AT(1A)-deficient, and cPLA2-alpha-deficient mice. In addition, Ang II failed to induce a significant ERK phosphorylation In the presence of arachidonic acid or 5,6-EET. Arachidonic acid or 5,6-EET also suppressed the stimulatory effect of Ang II on net proximal tubule bicarbonate absorption without changing cell Call concentrations. These results indicate that the cPLA(2)-alpha/P450/EET pathway blocks the stimulatory effect of Ang II by suppressing the ERK activation. Thus, the cPLA2-a/P450/EET pathway may operate as a unique negative feedback mechanism to attenuate excessive Ang II activity in the renal proximal tubules, where extremely high concentrations of Ang II are found. (Hypertens Res 2008; 31: 2155-2164)

语种英语
WOS记录号WOS:000264048500008
资助机构Ministry of Education, Culture, Sports, Science and Technology of Japan
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49978
专题北京大学第二临床医学院_肾内科
作者单位1.Univ Tokyo, Fac Med, Dept Internal Med, Bunkyo Ku, Tokyo 1130013, Japan
2.Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Bunkyo Ku, Tokyo 1130013, Japan
3.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
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GB/T 7714
Li, Yuchong,Yamada, Hideomi,Kita, Yoshihiro,et al. Arachidonic Acid Metabolites Inhibit the Stimulatory Effect of Angiotensin II in Renal Proximal Tubules[J]. HYPERTENSION RESEARCH,2008,31(12):2155-2164.
APA Li, Yuchong.,Yamada, Hideomi.,Kita, Yoshihiro.,Suzuki, Masashi.,Endo, Yoko.,...&Fujita, Toshiro.(2008).Arachidonic Acid Metabolites Inhibit the Stimulatory Effect of Angiotensin II in Renal Proximal Tubules.HYPERTENSION RESEARCH,31(12),2155-2164.
MLA Li, Yuchong,et al."Arachidonic Acid Metabolites Inhibit the Stimulatory Effect of Angiotensin II in Renal Proximal Tubules".HYPERTENSION RESEARCH 31.12(2008):2155-2164.
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