IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Antitumor and Immunomodulatory effects of polysaccharides from broken-spore of Ganoderma lucidum
Wang, Peng-Yun; Zhu, Xiao-Ling; Lin, Zhi-Bin
关键词Ganoderma Lucidum Spores Polysaccharide Antitumor Activity Cytokines Lymphocytes Nk Cells Macrophages
刊名FRONTIERS IN PHARMACOLOGY
2012
DOI10.3389/fphar.2012.00135
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

The antitumor and immunomodulatory activity of broken-spore of Ganoderma lucidum polysaccharides (G/-BSP) were investigated in vivo and in vitro. It was showed that G/-BSP (50, 100, and 200 mg kg(-1)) exhibited antitumor effect against Sarcoma 180 (S180) in BALB/c mice. The G/-BSP was not cytotoxicity in S180 cells and PG cells (human lung carcinoma cell) in vitro. However, serum from G/-BSP-treated S180-bearing mice significantly inhibited S180 and PG cells proliferation in vitro. Moreover, GI-BSP promoted the splenic lymphocyte proliferation induced by Con A or LPS, enhanced nature killer cell (NK cell) cytotoxic activity, augmented the percentage of neutral red phagocytosis by macrophages, and increased the percentage of the CD4(+) or CD8(+) subset in S180-bearing mice. The serum level of I FN-gamma, TNF-alpha, and nitric oxide was increased by GI-BSP. GI-BSP also showed immunomodulatory activities in tumor-bearing mice. Furthermore, neutralization with anti-INF-alpha and/or anti-IFN-gamma significantly diminished growth inhibition induced by G/-BSP-treated serum of S180-bearing mice in S180 or PG cells. These observations suggest that the antitumor activity of GI-BSP may be mainly related to the activation of the immune response of the host organism by the stimulation of NK cells, T cells, and macrophages.

语种英语
WOS记录号WOS:000209177700130
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49983
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
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Wang, Peng-Yun,Zhu, Xiao-Ling,Lin, Zhi-Bin. Antitumor and Immunomodulatory effects of polysaccharides from broken-spore of Ganoderma lucidum[J]. FRONTIERS IN PHARMACOLOGY,2012,3.
APA Wang, Peng-Yun,Zhu, Xiao-Ling,&Lin, Zhi-Bin.(2012).Antitumor and Immunomodulatory effects of polysaccharides from broken-spore of Ganoderma lucidum.FRONTIERS IN PHARMACOLOGY,3.
MLA Wang, Peng-Yun,et al."Antitumor and Immunomodulatory effects of polysaccharides from broken-spore of Ganoderma lucidum".FRONTIERS IN PHARMACOLOGY 3(2012).
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