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学科主题: 基础医学
题名:
Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma
作者: Wang, Meirong1,2; Qiu, Ning1,2; Lu, Shichun3,4; Xiu, Dianrong5; Yu, Jianguo6; Wang, Xing Tai7; Lu, Fengmin1,2; Li, Tong1,2; Liu, Xueen1,2; Zhuang, Hui1,2
关键词: hepatitis B virus ; hepatitis B surface antigen ; covalently closed circular DNA ; total HBV DNA ; hepatocellular carcinoma ; chronic hepatitis B
刊名: JOURNAL OF MEDICAL VIROLOGY
发表日期: 2013-02-01
DOI: 10.1002/jmv.23461
卷: 85, 期:2, 页:219-227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: CLOSED CIRCULAR DNA ; VIRUS DNA ; VIRAL LOAD ; HBSAG SEROCLEARANCE ; ANTIVIRAL THERAPY ; INFECTED PATIENTS ; NATURAL-HISTORY ; LIVER ; RISK ; QUANTITATION
英文摘要:

The aim of the study was to investigate correlations between intrahepatic hepatitis B virus total DNA, covalently closed circular DNA (cccDNA), and serum HBsAg in treatment-naive chronic hepatitis B and HBV related hepatocellular carcinoma (HCC). Liver tissues were taken from 42 HBV related HCC and 36 patients with chronic hepatitis B. A fraction of DNA extracted from liver tissue was digested with a plasmid-safe ATP-dependent DNase and used for HBV cccDNA detection. The remaining DNA was used for the detection of HBV total DNA and beta-globin, the latter of which is a housekeeping gene and quantified for normalization by real-time PCR. Quantitation of serum HBsAg was performed by a chemiluminescence assay. Serum HBsAg had positive correlations with serum HBV DNA (r?=?0.636, P?

语种: 英语
所属项目编号: 2013ZX10002004 ; 2012ZX10002003
项目资助者: Major Science and Technology Special Project of China Twelfth Five-year Plan
WOS记录号: WOS:000312544400006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/49989
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Capital Med Univ, Dept Hepatobiliary Surg, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Youan Hosp, Liver Transplantat Ctr, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Dept Surg, Beijing 100871, Peoples R China
6.Peoples Liberat Army, Hosp 88, Liver Dis Ctr, Dept Internal Med, Tai An, Shandong, Peoples R China
7.Bur Lab Sci, Div Mol Diagnost & Virol, Massachusetts Dept Publ Hlth, William A Hinton State Lab Inst, Boston, MA USA

Recommended Citation:
Wang, Meirong,Qiu, Ning,Lu, Shichun,et al. Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma[J]. JOURNAL OF MEDICAL VIROLOGY,2013,85(2):219-227.
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