IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma
Wang, Meirong1,2; Qiu, Ning1,2; Lu, Shichun3,4; Xiu, Dianrong5; Yu, Jianguo6; Wang, Xing Tai7; Lu, Fengmin1,2; Li, Tong1,2; Liu, Xueen1,2; Zhuang, Hui1,2
关键词hepatitis B virus hepatitis B surface antigen covalently closed circular DNA total HBV DNA hepatocellular carcinoma chronic hepatitis B
刊名JOURNAL OF MEDICAL VIROLOGY
2013-02-01
DOI10.1002/jmv.23461
85期:2页:219-227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]CLOSED CIRCULAR DNA ; VIRUS DNA ; VIRAL LOAD ; HBSAG SEROCLEARANCE ; ANTIVIRAL THERAPY ; INFECTED PATIENTS ; NATURAL-HISTORY ; LIVER ; RISK ; QUANTITATION
英文摘要

The aim of the study was to investigate correlations between intrahepatic hepatitis B virus total DNA, covalently closed circular DNA (cccDNA), and serum HBsAg in treatment-naive chronic hepatitis B and HBV related hepatocellular carcinoma (HCC). Liver tissues were taken from 42 HBV related HCC and 36 patients with chronic hepatitis B. A fraction of DNA extracted from liver tissue was digested with a plasmid-safe ATP-dependent DNase and used for HBV cccDNA detection. The remaining DNA was used for the detection of HBV total DNA and beta-globin, the latter of which is a housekeeping gene and quantified for normalization by real-time PCR. Quantitation of serum HBsAg was performed by a chemiluminescence assay. Serum HBsAg had positive correlations with serum HBV DNA (r?=?0.636, P?

语种英语
WOS记录号WOS:000312544400006
项目编号2013ZX10002004 ; 2012ZX10002003
资助机构Major Science and Technology Special Project of China Twelfth Five-year Plan
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49989
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Capital Med Univ, Dept Hepatobiliary Surg, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Youan Hosp, Liver Transplantat Ctr, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Dept Surg, Beijing 100871, Peoples R China
6.Peoples Liberat Army, Hosp 88, Liver Dis Ctr, Dept Internal Med, Tai An, Shandong, Peoples R China
7.Bur Lab Sci, Div Mol Diagnost & Virol, Massachusetts Dept Publ Hlth, William A Hinton State Lab Inst, Boston, MA USA
推荐引用方式
GB/T 7714
Wang, Meirong,Qiu, Ning,Lu, Shichun,et al. Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma[J]. JOURNAL OF MEDICAL VIROLOGY,2013,85(2):219-227.
APA Wang, Meirong.,Qiu, Ning.,Lu, Shichun.,Xiu, Dianrong.,Yu, Jianguo.,...&Zhuang, Hui.(2013).Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma.JOURNAL OF MEDICAL VIROLOGY,85(2),219-227.
MLA Wang, Meirong,et al."Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma".JOURNAL OF MEDICAL VIROLOGY 85.2(2013):219-227.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Serum hepatitis B su(453KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Meirong]的文章
[Qiu, Ning]的文章
[Lu, Shichun]的文章
百度学术
百度学术中相似的文章
[Wang, Meirong]的文章
[Qiu, Ning]的文章
[Lu, Shichun]的文章
必应学术
必应学术中相似的文章
[Wang, Meirong]的文章
[Qiu, Ning]的文章
[Lu, Shichun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naive patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。