|Effects of Length of Abstinence on Decision-Making and Craving in Methamphetamine Abusers|
|Wang, Guibin; Shi, Jie; Chen, Na; Xu, Lingzhi; Li, Jiali; Li, Peng; Sun, Yan; Lu, Lin|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||HEROIN ; INCUBATION ; COCAINE ; SEEKING ; STRESS ; USERS ; INDIVIDUALS ; IMPULSIVITY ; WITHDRAWAL ; ADDICTION|
Rationale: The majority of drug abusers are incapable of sustaining abstinence over any length of time. Accumulating evidence has linked intense and involuntary craving, Impulsive decision-making and mood disturbances to risk for relapse. However, little is known about temporal changes of these neuropsychological functions in methamphetamine (METH)dependent individuals.
Objectives: To investigate the effect of length of abstinence on decision-making, craving (baseline and cue-induced), and emotional state in METH-addicted individuals.
Methods: In this cross-sectional study, 183 adult METH-dependent patients at an addiction rehabilitation center who were abstinent for 6 days (n = 37), 14 days (n = 33), 1 month (n = 31), 3 months (n = 30), 6 months (n = 26), or 1 year (n = 30) and 39 healthy subjects were administered the Iowa Gambling Task (IGT) to assess decision-making performance. Depression, anxiety, and impulsivity were also examined. One hundred thirty-nine METH abusers who were abstinent for the aforementioned times then underwent a cue session, and subjective and physiological measures were assessed.
Results: METH dependent individuals who were abstinent for longer periods of time exhibited better decision-making than those who were abstinent for shorter periods of time. And self-reported emotional symptoms improved with abstinence. METH abusers′ ratings of craving decreased with the duration of abstinence, while cue-induced craving increased until 3 months of abstinence and decreased at 6 months and 1 year of abstinence.
Conclusions: We present time-dependent alterations in decision-making, emotional state, and the incubation of cue-induced craving in METH-dependent individuals, which might have significant clinical implications for the prevention of relapse.
|项目编号||81000571 ; 81225009 ; 2009CB522000 ; 91132719|
|资助机构||Natural Science Foundation of China ; National Science foundation for Distinguished Young Scholars of China ; National Basic Program of China|
|作者单位||Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China|
|Wang, Guibin,Shi, Jie,Chen, Na,et al. Effects of Length of Abstinence on Decision-Making and Craving in Methamphetamine Abusers[J]. PLOS ONE,2013,8(7).|
|APA||Wang, Guibin.,Shi, Jie.,Chen, Na.,Xu, Lingzhi.,Li, Jiali.,...&Lu, Lin.(2013).Effects of Length of Abstinence on Decision-Making and Craving in Methamphetamine Abusers.PLOS ONE,8(7).|
|MLA||Wang, Guibin,et al."Effects of Length of Abstinence on Decision-Making and Craving in Methamphetamine Abusers".PLOS ONE 8.7(2013).|