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学科主题基础医学
SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma
Jia, Yan1,2; Yang, Yunsheng1; Liu, Shuang3; Herman, James G.4; Lu, Fengmin5; Guo, Mingzhou1
关键词DNA methylation hepatocellular carcinoma SOX17 5-aza-2 &prime -deoxycytidine WNT signaling pathway
刊名EPIGENETICS
2010-11-01
DOI10.4161/epi.5.8.13104
5期:8页:743-749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]BETA-CATENIN ; COLORECTAL-CANCER ; STEM-CELLS ; EPIGENETIC INACTIVATION ; MOLECULAR PATHOGENESIS ; COLON-CARCINOMA ; ALPHA-CATENIN ; EXPRESSION ; PROTEINS ; DISEASE
英文摘要

SRY-box containing gene 17 (SOX17) was reported to be indispensable for embryonic development and a candidate tumor suppressor gene which antagonizes the canonical WNT/beta-catenin signaling pathway in colorectal cancer. In this study, we investigated the function and epigenetic regulation of SOX17 in human hepatocellular carcinoma (HCC). DNA methylation of SOX17 was analyzed in 62 human HCC tissues and HCC cell lines by MSP. A role as a tumor suppressor gene was evaluated by colony formation assay and regulation of WNT/beta-catenin signal pathway by SOX17 was determined by IHC and luciferase reporter assay. DNA methylation of the SOX17 promoter region occurs in 82% of HCC tissues and is associated with nuclear accumulation of beta-catenin. Restoration of SOX17 inhibits HepG2 colony formation and beta-catenin/TCF-dependent transcription with the presence of HMG box in SOX17. In conclusion, SOX17 negatively regulates canonical WNT/beta-catenin signaling pathway and inhibits human HCC cells growth, providing an explanation for the loss of expression by epigenetic mechanisms in these tumors.

语种英语
WOS记录号WOS:000284263500010
项目编号2010CB912802 ; 2009ZX10004-903
资助机构National Basic Research Program (973 Program) ; National S& ; T Major Project for Infections Control
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/49998
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China
2.Nankai Univ, Coll Med, Tianjin 300071, Peoples R China
3.Capital Med Univ, Beijing Youan Hosp, Beijing, Peoples R China
4.Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
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Jia, Yan,Yang, Yunsheng,Liu, Shuang,et al. SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma[J]. EPIGENETICS,2010,5(8):743-749.
APA Jia, Yan,Yang, Yunsheng,Liu, Shuang,Herman, James G.,Lu, Fengmin,&Guo, Mingzhou.(2010).SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma.EPIGENETICS,5(8),743-749.
MLA Jia, Yan,et al."SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma".EPIGENETICS 5.8(2010):743-749.
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