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Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic Stem Cell Transplantation
Han, Wei; Wang, Yu; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Zhang, Xiao-Hui; Chen, Huan; Chen, Yu-Hong; Huang, Xiao-Jun
关键词Acute Myeloid Leukemia Response Cytogenetics Risk Transplantation
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2013-02-01
DOI10.1016/j.bbmt.2012.10.002
19期:2页:283-290
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]MINIMAL RESIDUAL DISEASE ; 1ST COMPLETE REMISSION ; BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOBLASTIC-LEUKEMIA ; DONOR LYMPHOCYTE INFUSION ; AML 10 TRIAL ; POSTREMISSION THERAPY ; CYTOGENETICS ; RELAPSE ; BLOOD
英文摘要

The impact of risk-related parameters has not been defined in transplantation settings. We wondered whether the currently recognized predictors could be used to categorize acute myeloid leukemia (AML) patients who underwent transplantation during remission into risk groups. We analyzed the data of 255 consecutive patients (median age, 26) with AML in their first or second remission (CR1 or CR2) after haploidentical hematopoietic stem cell transplantation (HSCT). Three parameters were found to be predictive of outcome: response after induction therapy, white blood cell count at diagnosis, and cytogenetics. These three factors were combined to yield two risk groups. The 2-year cumulative incidences of relapse for patients at low and high risk were 8% and 36% (P = .001), respectively. The 3-year probabilities of leukemia-free survival for these two groups were 80% and 52% (P = .001), respectively. Multivariate analysis for relapse and for leukemia-free survival showed that not achieving CR after two courses of therapy was the strongest independent prognostic factor (P = .001 and P = .028, respectively). In addition, in a subgroup of patients with quantification of minimal residual disease at the time of HSCT, positive minimal residual disease at this time point was correlated with a poor outcome. Our results suggest that the pretransplantation risk factors influence posttransplantation outcomes of patients with AML in CR after haploidentical HSCT and might be applicable to assist with risk-directed posttransplantation therapy. (C) 2013 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000314441700020
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50002
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Han, Wei,Wang, Yu,Liu, Dai-Hong,et al. Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2013,19(2):283-290.
APA Han, Wei.,Wang, Yu.,Liu, Dai-Hong.,Liu, Kai-Yan.,Xu, Lan-Ping.,...&Huang, Xiao-Jun.(2013).Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic Stem Cell Transplantation.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,19(2),283-290.
MLA Han, Wei,et al."Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic Stem Cell Transplantation".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19.2(2013):283-290.
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