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学科主题: 临床医学
题名:
Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic Stem Cell Transplantation
作者: Han, Wei; Wang, Yu; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Zhang, Xiao-Hui; Chen, Huan; Chen, Yu-Hong; Huang, Xiao-Jun
关键词: Acute myeloid leukemia ; Response ; Cytogenetics ; Risk ; Transplantation
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2013-02-01
DOI: 10.1016/j.bbmt.2012.10.002
卷: 19, 期:2, 页:283-290
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: MINIMAL RESIDUAL DISEASE ; 1ST COMPLETE REMISSION ; BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOBLASTIC-LEUKEMIA ; DONOR LYMPHOCYTE INFUSION ; AML 10 TRIAL ; POSTREMISSION THERAPY ; CYTOGENETICS ; RELAPSE ; BLOOD
英文摘要:

The impact of risk-related parameters has not been defined in transplantation settings. We wondered whether the currently recognized predictors could be used to categorize acute myeloid leukemia (AML) patients who underwent transplantation during remission into risk groups. We analyzed the data of 255 consecutive patients (median age, 26) with AML in their first or second remission (CR1 or CR2) after haploidentical hematopoietic stem cell transplantation (HSCT). Three parameters were found to be predictive of outcome: response after induction therapy, white blood cell count at diagnosis, and cytogenetics. These three factors were combined to yield two risk groups. The 2-year cumulative incidences of relapse for patients at low and high risk were 8% and 36% (P = .001), respectively. The 3-year probabilities of leukemia-free survival for these two groups were 80% and 52% (P = .001), respectively. Multivariate analysis for relapse and for leukemia-free survival showed that not achieving CR after two courses of therapy was the strongest independent prognostic factor (P = .001 and P = .028, respectively). In addition, in a subgroup of patients with quantification of minimal residual disease at the time of HSCT, positive minimal residual disease at this time point was correlated with a poor outcome. Our results suggest that the pretransplantation risk factors influence posttransplantation outcomes of patients with AML in CR after haploidentical HSCT and might be applicable to assist with risk-directed posttransplantation therapy. (C) 2013 American Society for Blood and Marrow Transplantation.

语种: 英语
所属项目编号: 30971292 ; 2008zx09312-026
项目资助者: National Natural Science Foundation of China ; National High-tech R&amp ; D Program of China ; Ministry of Health of China ; National Scientific Major Program-major new drug formulation ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation ; Leading Program of Clinical Faculty
WOS记录号: WOS:000314441700020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50002
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Han, Wei,Wang, Yu,Liu, Dai-Hong,et al. Impact of Pretransplantation Risk Factors on Post Transplantation Outcome of Patients with Acute Myeloid Leukemia in Remission after Haploidentical Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2013,19(2):283-290.
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