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学科主题: 临床医学
题名:
The Electrophysiology Analysis of Biological Conduit Sleeve Bridging Rhesus Monkey Median Nerve Injury with Small Gap
作者: Zhang, Peixun; Yin, Xiaofeng; Kou, Yuhui; Wang, Yanhu; Zhang, Hongbo; Jiang, Baoguo
关键词: Peripheral nerves ; nerve regeneration ; conduit
刊名: ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
发表日期: 2008
DOI: 10.1080/10731190802375802
卷: 36, 期:5, 页:457-463
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Biotechnology & Applied Microbiology ; Engineering ; Materials Science
英文摘要:

Based on the research on small gap bridging peripheral nerve injury in SD rats, we propose to investigate the possibility of bridging peripheral nerve injury with small gap using a de-acetyl chitin conduit in primates. The median nerves of 8 rhesus monkeys were cut at 2 cm above the elbow; the right sides were subjected to small gap (2 mm) bridging to repair the nerve with chitin conduit (conduit inner diameter 4 mm; length 10 mm); the left sides were subjected to traditionary epineurium suture. The electrophysiology analysis was conducted after the 3rd month and 6th month, respectively. The adhesions condition of biological conduit was only a little after the 15 3rd month; the conduit can remain cast contour; vessels can be seen on the conduit 16 surface and nerve intumescentia was not obvious. The adhesion and intumescentia condition can display better biocompatibilities than traditional suture methods. The motor nerve conduction velocity was only 1/2 of the control group. Although the motor nerve conduction velocity of the conduit group was a little higher than the epineurium suture group, there was no statistically significant difference (P > 0.05) at the 3rd month (Table 1). The conduit cast contour disappeared after 6 months. The motor nerve conduction velocity was only 4/5 of the control group. The motor nerve conduction velocity of the conduit group was higher than the epineurium suture group; there were statistically significant differences (P < 0.05) at 6 months. The nerve trunk conduction velocity of biological conduit was higher than the epineurium suture group at the 6th month, and there were statistically significant differences (P < 0.05) (Table 2). The biocompatibility of the biological chitin conduit in primate rhesus monkeys was quite good. The electrophysiological results of biological conduit in primate rhesus monkeys were better than the traditional epineurium suture. The biological conduit can be used in primate rhesus monkeys to substitute for the traditional epineurium suture methods.

语种: 英语
所属项目编号: 30625036 ; 2003CB515306 ; 30801169 ; 20070001780
项目资助者: China National Natural Science Funds ; China 973 Projection ; China Nature Science Youth Foundation ; China Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000260558700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50004
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Peixun,Yin, Xiaofeng,Kou, Yuhui,et al. The Electrophysiology Analysis of Biological Conduit Sleeve Bridging Rhesus Monkey Median Nerve Injury with Small Gap[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2008,36(5):457-463.
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