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学科主题药学
Pharmacokinetics and brain distribution differences of baicalin in rat underlying the effect of Panax notoginsenosides after intravenous administration
Yang Yan-Fang1,2; Li Zhi1,3,4; Xin Wen-Feng5; Wang Yong-Yan3,4; Zhang Wen-Sheng1,3,4,5
关键词Baicalin Panax Notoginsenosides Rat Plasma Rat Brain Pharmacokinetics Hplc/ms/ms
刊名CHINESE JOURNAL OF NATURAL MEDICINES
2014-08-01
DOI10.3724/SP.J.1009.2014.00632
12期:8页:632-640
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Key New Drug Creation and Development Program of China ; National Key Technology R D Program ; National Natural Science Foundation of China ; Key New Drug Creation and Development Program of China ; National Key Technology R D Program
研究领域[WOS]Integrative & Complementary Medicine ; Pharmacology & Pharmacy
关键词[WOS]RADIX-SCUTELLARIAE EXTRACT ; JIE-DU-TANG ; CEREBROSPINAL-FLUID ; MASS-SPECTROMETRY ; CEREBRAL-ISCHEMIA ; PURE BAICALIN ; BLOOD
英文摘要

Baicalin (BA) is the most well-known flavonoid present in Radix Scutellariae. The aim of this study was to explore whether the pharmacokinetic behavior of BA in rat brain can be affected by Panax notoginsenosides (PNS), and to assess the possible mechanism for the observed effects. Specific HPLC and HPLC/MS/MS methods were developed and validated for the determination of BA in the rat plasma and brain using carbamazepine as an internal standard. BA was found to enter rat brain quickly after a single intravenous dose. When co-administered with PNS, clearance (CL) of BA from rat plasma decreased by 50.00%, while the area under the curve AUC(0-t) and AUC(0-infinity) increased 94.69% and 87.68%, respectively. On the other hand, some pharmacokinetic parameters of BA in rat brain had obvious differences after PNS was administered, such as an increase in T-max from 5 min to 15 mm, an increase in AUC(0-t) and AUC(0-infinity) by 42.75% and 29.39%, respectively, as well as a decrease in CL by 27.95%. Together, these results indicate that PNS can decrease the elimination rate of BA from rat plasma, promote the penetration of BA into rat brain, increase the concentration and slow down the elimination of BA from rat brain. The data provide important information that compatibility with PNS can promote the consequent effects of BA for the treatment of encephalopathy.

语种英语
所属项目编号81274118 ; 2012 ZX09103-201 ; 2012BAI29B08
资助者National Natural Science Foundation of China ; Key New Drug Creation and Development Program of China ; National Key Technology R D Program ; National Natural Science Foundation of China ; Key New Drug Creation and Development Program of China ; National Key Technology R D Program
WOS记录号WOS:000342108100012
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50005
专题北京大学药学院
作者单位1.Engn Res Ctr Sanqi Biotechnol & Pharmaceut, Kunming 650000, Peoples R China
2.Beijing Normal Univ, State Key Lab Earth Surface Proc & Resource Ecol, Beijing 100875, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
4.Minist Educ, Engn Res Ctr Nat Med, Beijing 100875, Peoples R China
5.Beijing Normal Univ, Coll Resources Sci & Technol, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714
Yang Yan-Fang,Li Zhi,Xin Wen-Feng,et al. Pharmacokinetics and brain distribution differences of baicalin in rat underlying the effect of Panax notoginsenosides after intravenous administration[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(8):632-640.
APA Yang Yan-Fang,Li Zhi,Xin Wen-Feng,Wang Yong-Yan,&Zhang Wen-Sheng.(2014).Pharmacokinetics and brain distribution differences of baicalin in rat underlying the effect of Panax notoginsenosides after intravenous administration.CHINESE JOURNAL OF NATURAL MEDICINES,12(8),632-640.
MLA Yang Yan-Fang,et al."Pharmacokinetics and brain distribution differences of baicalin in rat underlying the effect of Panax notoginsenosides after intravenous administration".CHINESE JOURNAL OF NATURAL MEDICINES 12.8(2014):632-640.
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