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学科主题: 临床医学
题名:
Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer
作者: Tsang, Julia Y. S.1; Huang, Yu-Hua2; Luo, Ming-Hua3; Ni, Yun-Bi1; Chan, Siu-Ki4; Lui, Philip C. W.5; Yu, Alex M. C.5; Tan, Puay Hoon6; Tse, Gary M.1
关键词: Cancer stem cell ; Breast cancer subtype ; Aldehyde dehydrogenase 1 ; CD24 ; CD44
刊名: BREAST CANCER RESEARCH AND TREATMENT
发表日期: 2012-11-01
DOI: 10.1007/s10549-012-2271-6
卷: 136, 期:2, 页:407-417
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: POOR-PROGNOSIS ; PHENOTYPE ; RECEPTOR ; ALDH1 ; CD44(+)/CD24(-/LOW) ; IDENTIFICATION ; EXPRESSION ; ESTROGEN ; STAGE ; CD44
英文摘要:

Cumulative evidence has demonstrated the presence of cancer stem cells (CSC) in breast cancer and its putative role in cancer progression. Nonetheless, the clinical significance of CSC in breast cancer remains elusive. The underlying reasons could be due to the heterogeneity of breast cancer subtypes as well as different markers used to define breast CSC. In this study, three widely used markers (aldehyde dehydrogenase (ALDH)1+ and CD24-CD44+) were used to define two populations of CSC in a large cohort of breast cancers. The expressions of these markers were correlated with different clinicopathological features and the molecular subtypes. ALDH1+ breast cancers were associated with basal-like and HER2-overexpressing subtypes and the characteristics histologic features were related to these two subtypes. On the other hand, CD24-CD44+ breast cancers were associated positively with the presence of extensive in situ component, the absence of lymph node involvement, and basal markers, but negatively with HER2. CD24-CD44+ breast cancers were also positively associated with luminal B cancers. As the expression of CSC markers varied among different molecular subtypes and different clinicopathological features, it appeared that each CSC population could have distinct clinical values in different subgroups of breast cancers. For improved prognostication with CSC, combining the analysis of CSC markers would be required. Within the luminal cancers, CSC appeared to identify cancers with poor outcome. The presence of CSC populations was associated with ER-PR+ cancers and tumors expressing basal markers. Basal marker expression can complement with CSC for improved indicator for poor prognosis in luminal breast cancers. For the first time, the possible contribution of CSC to these aggressive luminal cancers was demonstrated. The association of basal features and CSC in luminal cancers also raised the possibility that luminal cancer cells may acquire basal phenotype and CSC properties together during their progression.

语种: 英语
WOS记录号: WOS:000310378700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50009
Appears in Collections:北京大学深圳医院_病理科_期刊论文

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作者单位: 1.Shenzhen Second People Hosp, Dept Pathol, Shenzhen, Peoples R China
2.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen, Peoples R China
4.Kwong Wah Hosp, Dept Pathol, Kowloon, Hong Kong, Peoples R China
5.Union Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
6.Singapore Gen Hosp, Dept Pathol, Singapore 0316, Singapore

Recommended Citation:
Tsang, Julia Y. S.,Huang, Yu-Hua,Luo, Ming-Hua,et al. Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer[J]. BREAST CANCER RESEARCH AND TREATMENT,2012,136(2):407-417.
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