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Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study
Ding, L1; Zhao, MH1; Zou, WZ1; Liu, YC1; Wang, HY1
关键词Lupus Nephritis Mycophenolate Mofetil Pathology
刊名LUPUS
2004
DOI10.1191/0961203304lu513oa
13期:2页:113-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]RAT REMNANT KIDNEY ; GLOMERULAR-DISEASES ; RENAL INJURY ; CELLS ; ACID ; GLOMERULONEPHRITIS ; OSTEOPONTIN ; PROGRESSION ; EXPRESSION ; CYTOKINES
英文摘要

Mycophenolate mofetil (MMF) is a potential new treatment for diffuse proliferative lupus nephritis. This study examines the clinical and histopathological effects, and potential mechanisms, of combination MMF/prednisone therapy in diffuse proliferative lupus nephritis. Nine patients with diffuse proliferative lupus nephritis confirmed by renal biopsy received MMF/prednisone for six months when repeat biopsies were performed. Clinical and histopathological parameters of activity and chronicity were studied. Collagens were detected by Sirus red staining; leucocyte phenotype, osteopontin (OPN), fibrinectin (FN), alpha-smooth muscle actin (alpha-SMA) and TGF-beta1 were detected by immunohistochemistry. The changes of clinical and histopathologic parameters were assessed and compared to histopathologic indicators. Eight of the nine patients achieved clinical remission; renal function deteriorated in one. Histopathological activity indices reduced significantly (9.56 +/- 2.83 versus 5.22 +/- 1.86, P < 0.01); however, the chronicity indices did not change (3.56 +/- 1.42 versus 3.22 +/- 1.20). T-cell and monocyte/macrophage infiltration, OPN expression and the percentage of proliferative cells in both glomerulus and tubulo-interstitium decreased significantly. Other features of chronic lesions, except for glomerular collagen deposition, did not change. In conclusion, MMF/prednisone therapy was effective for our patients with proliferative lupus nephritis. The active inflammatory lesions could be ameliorated through reduction of lymphocyte and monocyte/ macrophage infiltration, inhibition of cell proliferation and downregulation of adhesive molecules. However, the chronic fibrotic lesions could not be significantly reduced.

语种英语
WOS记录号WOS:000188956000007
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50018
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Renal Unit, Beijing 100034, Peoples R China
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GB/T 7714
Ding, L,Zhao, MH,Zou, WZ,et al. Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study[J]. LUPUS,2004,13(2):113-118.
APA Ding, L,Zhao, MH,Zou, WZ,Liu, YC,&Wang, HY.(2004).Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study.LUPUS,13(2),113-118.
MLA Ding, L,et al."Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study".LUPUS 13.2(2004):113-118.
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