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学科主题: 公共卫生
题名:
Vitamin B-12 and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate
作者: Wang, Tian-Cheng2; Jia, Guang1; Zhang, Ji3; Ma, Yan-Hui3; Liu, Lan-Zheng3; Zhang, Ning3; Feng, Wei-Yue4; Zhou, Jing-Wen3; Song, Yan-Shuang1; Yan, Lei1; Du, Xian-Mei1
刊名: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
发表日期: 2011-12-01
DOI: 10.1136/oem.2010.063305
卷: 68, 期:12, 页:870-875
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; IMPAIRED KIDNEY-FUNCTION ; SERUM CYSTATIN-C ; RENAL-FUNCTION ; OCCUPATIONAL-EXPOSURE ; HYPERTENSIVE PATIENTS ; METHYLMALONIC ACID ; ELECTROPLATING WORKERS ; PLATING WORKERS ; DAMAGE
英文摘要:

Objectives Chronic occupational exposure to chromium can result in a broad range of adverse effects including multiple organ damage, genotoxicity and carcinogenesis. However, the metabolic consequences of chromium exposure have not been fully investigated. This study was designed to examine vitamin B-12, folate and homocysteine metabolic changes in workers chronically exposed to chromate. The potential association between metabolic alteration and renal impairment induced by chromate exposure was also assessed.

Methods The level of chromium exposure was evaluated by measuring chromium concentrations in red blood cells (RBC-Cr) and urine (U-Cr). Renal impairment was assessed with serum cystatin C (Cys-C) and urinary beta(2)-microglobulin (beta M-2). Serum vitamin B-12, folate and plasma total homocysteine (tHcy) were measured and correlations analysed.

Results Significant increases in RBC-Cr, U-Cr, serum Cys-C, plasma tHcy and urinary beta M-2 concentrations were observed in workers chronically exposed to chromate compared to controls. In the exposed workers, serum vitamin B-12 and folate levels were decreased and significantly inversely correlated with RBC-Cr concentrations, and increased plasma tHcy concentrations were mirrored by decreased serum vitamin B-12 and folate levels. Elevated plasma tHcy concentrations were positively related to serum Cys-C concentrations.

Conclusions Hyperhomocysteinemia in chronically exposed workers was primarily induced by vitamin B-12 and folate deficiency. This metabolic change might be associated with renal dysfunction in chromate processing workers after long term exposure.

语种: 英语
所属项目编号: 30571550 ; 81072281 ; 2006BAI06B02 ; 200902006
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000296794600003
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50028
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Clin Labs, Beijing 100191, Peoples R China
3.Ctr Dis Control & Prevent Jinan City, Jinan, Shandong, Peoples R China
4.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci, Beijing, Peoples R China

Recommended Citation:
Wang, Tian-Cheng,Jia, Guang,Zhang, Ji,et al. Vitamin B-12 and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate[J]. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,2011,68(12):870-875.
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