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学科主题: 基础医学
题名:
High Surface-Enhanced Raman Scattering Performance of Individual Gold Nanoflowers and Their Application in Live Cell Imaging
作者: Li, Qi1; Jiang, Yuanyuan1; Han, Rongcheng2,3; Zhong, Xiaolan4; Liu, Siyun4; Li, Zhi-Yuan4; Sha, Yinlin2,3; Xu, Dongsheng1
关键词: gold nanoflowers ; surface-enhanced Raman scattering ; Raman imaging ; live cell imaging
刊名: SMALL
发表日期: 2013-03-25
DOI: 10.1002/smll.201201065
卷: 9, 期:6, 页:927-932
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: SILVER ELECTRODE ; OPTICAL-PROPERTIES ; SPECTROSCOPY ; NANOPARTICLES ; NANOCRYSTALS ; SERS ; 4-MERCAPTOPYRIDINE ; MICROSPECTROSCOPY ; DEPENDENCE ; PYRIDINE
英文摘要:

Molecular imaging techniques based on surface-enhanced Raman scattering (SERS) face a lack of reproducibility and reliability, thus hampering its practical application. Flower-like gold nanoparticles have strong SERS enhancement performance due to having plenty of hot-spots on their surfaces, and this enhancement is not dependent on the aggregation of the particles. These features make this kind of particle an ideal SERS substrate to improve the reproducibility in SERS imaging. Here, the SERS properties of individual flower-like gold nanoparticles are systematically investigated. The measurements reveal that the enhancement of a single gold nanoparticle is independent of the polarization of the excitation laser with an enhancement factor as high as 108. After capping with Raman signal molecules and folic acid, the gold nanoflowers show strong Raman signal in the living cells, excellent targeting properties, and a high signal-to-noise ratio for SERS imaging.

语种: 英语
所属项目编号: 50821061 ; 21073007 ; 20973008 ; 11104342 ; 2011CB808702 ; 2007CB936201 ; 2013CB632704
项目资助者: NSFC ; MSTC (NKBRSF)
WOS记录号: WOS:000316338800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50032
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Phys, Lab Opt Phys, Beijing 100190, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
3.Peking Univ, Dept Biophys, Sch Basic Med Sci, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China
4.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Qi,Jiang, Yuanyuan,Han, Rongcheng,et al. High Surface-Enhanced Raman Scattering Performance of Individual Gold Nanoflowers and Their Application in Live Cell Imaging[J]. SMALL,2013,9(6):927-932.
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