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学科主题: 精神卫生
题名:
Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population
作者: Li, J1; Wang, YF1; Zhou, RL1; Zhang, HB1; Yang, L1; Wang, B1; Faraone, SV1
关键词: tryptophan hydroxylase (TPH) ; serotonin ; genetic polymorphisms
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2006-03-05
DOI: 10.1002/ajmg.b.30260
卷: 141B, 期:2, 页:126-129
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: 5-HT1B RECEPTOR GENE ; DEFICIT/HYPERACTIVITY DISORDER ; A218C POLYMORPHISM ; TRANSPORTER GENE ; 7-REPEAT ALLELE ; SUICIDALITY ; AGGRESSION ; 5-HTTLPR ; PROMOTER ; ADHD
英文摘要:

Attention deficit hyperactivity disorder (ADHD) is a severe behavioral disorder in children known to have a substantial genetic component. Prior studies have implicated serotonin genes in the etiology of ADHD but have not examined tryptophan hydroxylase (TPH), which is a rate-limiting enzyme in serotonin biosynthesis. The current study examined the relationship between the A218C and A-6526G polymorphisms of the TPH gene and ADHD. Three hundred sixty-two unrelated ADHD probands and their biological parents were recruited to participate in this study. No biased transmission of any allele of the two polymorphisms was observed using TDT analysis. However, haplotype analyses found that the rare 218A/-6526G haplotype was significantly not transmitted to probands with ADHD (chi(2) = 4.4995, P = 0.034), regardless of subtype. Although this finding for ADHD in the Chinese Han population. (C) 2006 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000235142200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50033
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA

Recommended Citation:
Li, J,Wang, YF,Zhou, RL,et al. Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(2):126-129.
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