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Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population
Li, J1; Wang, YF1; Zhou, RL1; Zhang, HB1; Yang, L1; Wang, B1; Faraone, SV1
关键词Tryptophan Hydroxylase (Tph) Serotonin Genetic Polymorphisms
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2006-03-05
DOI10.1002/ajmg.b.30260
141B期:2页:126-129
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]5-HT1B RECEPTOR GENE ; DEFICIT/HYPERACTIVITY DISORDER ; A218C POLYMORPHISM ; TRANSPORTER GENE ; 7-REPEAT ALLELE ; SUICIDALITY ; AGGRESSION ; 5-HTTLPR ; PROMOTER ; ADHD
英文摘要

Attention deficit hyperactivity disorder (ADHD) is a severe behavioral disorder in children known to have a substantial genetic component. Prior studies have implicated serotonin genes in the etiology of ADHD but have not examined tryptophan hydroxylase (TPH), which is a rate-limiting enzyme in serotonin biosynthesis. The current study examined the relationship between the A218C and A-6526G polymorphisms of the TPH gene and ADHD. Three hundred sixty-two unrelated ADHD probands and their biological parents were recruited to participate in this study. No biased transmission of any allele of the two polymorphisms was observed using TDT analysis. However, haplotype analyses found that the rare 218A/-6526G haplotype was significantly not transmitted to probands with ADHD (chi(2) = 4.4995, P = 0.034), regardless of subtype. Although this finding for ADHD in the Chinese Han population. (C) 2006 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000235142200003
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50033
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Peking Univ Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA
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GB/T 7714
Li, J,Wang, YF,Zhou, RL,et al. Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(2):126-129.
APA Li, J.,Wang, YF.,Zhou, RL.,Zhang, HB.,Yang, L.,...&Faraone, SV.(2006).Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,141B(2),126-129.
MLA Li, J,et al."Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 141B.2(2006):126-129.
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