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学科主题基础医学
HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection
Shen, T.1,3; Zhang, C.4; Long, L.1; Duan, Z.1; Lu, F.1,3; Liu, Y.1,2
关键词anti-HCV antibodies CD4+T counts HCV HIV spontaneous recovery
刊名JOURNAL OF VIRAL HEPATITIS
2014-10-01
DOI10.1111/jvh.12238
21期:10页:690-695
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
资助者National S& ; T Major Project for Infectious Diseases ; National Natural Science of China ; National Science Foundation of Beijing ; National S& ; T Major Project for Infectious Diseases ; National Natural Science of China ; National Science Foundation of Beijing
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]SINGLE-SOURCE OUTBREAK ; HEPATITIS-C VIRUS ; SPONTANEOUS CLEARANCE ; VIRAL CLEARANCE ; VACCINATION ; DISEASE ; CHINA
英文摘要

Acute hepatitis C virus (HCV) infection is primarily followed by chronic infection, while spontaneous recovery of HCV infection (SR-HCV) occurs in a minority of those infected. Identification of SR-HCV clinically depends on two combined indicators, persistently undetectable peripheral HCV RNA and positivity for anti-HCV. However, the characteristics of dynamic variation in anti-HCV antibodies in SR-HCV, especially in those patients co-infected with HIV, are still undefined. In this study, a cohort of patients infected with HCV through commercial blood collection practices was studied. We found that the annual decreasing rate of anti-HCV presented a gradually accelerated process in HCV resolvers. However, the variation in the decline of anti-HCV presented a slowly accelerated process within the early decrease stage and a gradually decelerated process within the latter decrease stage. In addition, we deduced that it expended approximately 16years from natural HCV recovery to undetectable peripheral anti-HCV in HCV resolvers co-infected with HIV, while this time was estimated to be 20years in SR-HCV without HIV co-infection. Our data indicated that the decay of anti-HCV was accelerated by HIV-related impairment of immune function. The prevalence of HCV infection may be severely underestimated in this large-scale retrospective epidemiologic investigation in an HIV-infected population.

语种英语
所属项目编号2012ZX10002003 ; 2012ZX10002005 ; 81271826 ; 7122108
资助者National S& ; T Major Project for Infectious Diseases ; National Natural Science of China ; National Science Foundation of Beijing ; National S& ; T Major Project for Infectious Diseases ; National Natural Science of China ; National Science Foundation of Beijing
WOS记录号WOS:000341717400011
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50035
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Zhengzhou, Henan, Peoples R China
3.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Infect Dis, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Shen, T.,Zhang, C.,Long, L.,et al. HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection[J]. JOURNAL OF VIRAL HEPATITIS,2014,21(10):690-695.
APA Shen, T.,Zhang, C.,Long, L.,Duan, Z.,Lu, F.,&Liu, Y..(2014).HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection.JOURNAL OF VIRAL HEPATITIS,21(10),690-695.
MLA Shen, T.,et al."HIV co-infection accelerates decay of humoral responses in spontaneous resolvers of HCV infection".JOURNAL OF VIRAL HEPATITIS 21.10(2014):690-695.
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