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Tc-99m-3P(4)-RGD(2) radiotracers for SPECT/CT of esophageal tumor
Gao Shi1; Ma Qingjie1; Wen Qiang1; Jia Bing2; Liu Zhaofei2; Chen Zuowei3; Zhang Haishan1; Li Dandan1
关键词Tc-99m-3p(4)-rgd(2) Esophageal Tumor Spect Integrin Alpha v Beta 3
刊名NUCLEAR SCIENCE AND TECHNIQUES
2013-08-20
24期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nuclear Science & Technology ; Physics, Nuclear
研究领域[WOS]Nuclear Science & Technology ; Physics
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; ALPHA-V-BETA-3 INTEGRIN ; CANCER-PATIENTS
英文摘要

In recent years, several RGD (Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin alpha v beta 3, demonstrating its feasibility in tumor diagnosis. In this paper, we evaluated the Tc-99m-3P(4)-RGD(2) single photon emission computed tomography/computerized tomography (SPECT/CT) in patients suffering from space occupying disease of esophagus. 40 patients (34 males and 6 female; mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included, thus finally obtaining their definite pathologic diagnosis (malignant, n=32; benign, n=8). All patients underwent endoscopic, barium esophagography and SPECT/CT imaging preoperatively. The chest SPECT was performed at 4 h after administration of Tc-99m-3P(4)-RGD(2) with a dose of 939 +/- 118 MBq. The diagnosis precision, sensitivity and specificity among these methods were compared. The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus (T/N). Meanwhile, the integrin alpha v beta 3 expression was assessed immunohistochemically in postoperative esophageal tissues. 31 patients were diagnosed as esophageal carcinoma; and 1, leiomyosarcoma; and 6. leimyoma; and 2, esophageal tuberculosis. The accuracy, sensitivity and specificity of barium esophagography, endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%, 97.5/96.9/100%, and 90/90.6/87.5%, respectively. Abnormal accumulation of radiotracer in 29 malignant lesions is observed. The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the TIN ratio from 1.31 to 2.79 (mean 2.04). A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic. The Tc-99m-3P(4)-RGD(2) uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification (P>0.05). There was a significant positive correlation between T/N ratio and positive cell percentage of integrin alpha v beta 3 (r=0.976), demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma.

语种英语
WOS记录号WOS:000328922100008
项目编号201102154 ; 81271606 ; 201015185 ; 201201041
资助机构Research Fund of Shenzhen Sci-tech Department of Guangdong Province ; National Natural Science Foundation of China (NSFC) ; Research Fund of Science and Technology Department of Jilin Province
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50038
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
3.Peoples Hosp Shenzhen, Dept Nucl Med, Shenzhen 518020, Peoples R China
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GB/T 7714
Gao Shi,Ma Qingjie,Wen Qiang,et al. Tc-99m-3P(4)-RGD(2) radiotracers for SPECT/CT of esophageal tumor[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(4).
APA Gao Shi.,Ma Qingjie.,Wen Qiang.,Jia Bing.,Liu Zhaofei.,...&Li Dandan.(2013).Tc-99m-3P(4)-RGD(2) radiotracers for SPECT/CT of esophageal tumor.NUCLEAR SCIENCE AND TECHNIQUES,24(4).
MLA Gao Shi,et al."Tc-99m-3P(4)-RGD(2) radiotracers for SPECT/CT of esophageal tumor".NUCLEAR SCIENCE AND TECHNIQUES 24.4(2013).
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